Results 81 to 90 of about 872,727 (291)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Building professional discourse in emerging markets: Language, context and the challenge of sensemaking [PDF]

, 2013
Using ethnographic evidence from the former Soviet republics, this article examines a relatively new and mainly unobserved in the International Business (IB) literature phenomenon of communication disengagement that manifests itself in many emerging ...
A Denzau, A Kuznetsov, A-W Harzing, AD Jankowicza, AE Witte, Andrei Kuznetsov, AS Tsui, B-L Gunnarsson, C Bartlett, C Gibson, C Kindleberger, C Oswick, C Prahalad, C Wilkinson, CM Vance, D Elenkov, D Grant, D Grant, D Mowery, D Ursic, DE Westney, DM Boje, DV Caprar, DW De Long, E Jacobs, E Ochs, E Vaara, EH Schein, F Kotler, F Moore, G Fink, G Hollinshead, G Hollinshead, H Botti, H Bresman, I Alon, I Pshenichnikova, J Birkinshaw, J Clausen, J Van Maanen, K Fischer, K Weick, L Venuti, M Alvesson, M Boisot, M Branine, M Branine, MA Witt, MY Brannen, N Fairclough, N Fairclough, N Fairclough, N Fairclough, N Holden, N Holden, N Holden, N Holden, N Holden, N Holden, N Holden, N Holden, N Holden, N Napier, N Phillips, N Yagi, O Kuznetsova, Olga Kuznetsova, P Buckley, R Fox, R Marschan-Piekkari, R May, R May, S Blazejewski, S Hymer, S Magala, S Michailova, S Michailova, S Rodrigues, S Tietze, S Tietze, S Tietze, S Zaheer, T Kostova, T Nishiguchi, T Watson, V Peltokorpi, V Peltokorpi, V Vaiman, W Schramm, Y Luo, Y Mirkin   +90 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Organising water: The hidden role of intermediary work [PDF]

, 2009
: The increasingly complex challenges of making water management more sustainable require a critical and detailed understanding of the social organisation of water. This paper examines the hitherto neglected role that 'intermediary' organisations play in
Guy, S, Marvin, S, Medd, W, Moss, T
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Teaching and researching literary translation in the digital context: PEnPAL in trans as a case-study

MatLit, 2016
The digital reinvention of literary studies within literary translation teaching and research informs the PEnPAL in Trans project. This inter-institutional venture joins higher education agents and researchers in Translation Studies, Literary Studies and
Gato, Margarida Vale de, Janssen, Maarten, Barros, Rita Queiroz de, Valdez, Susana   +3 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

American Institutions and Economic Progress

Scienza & Politica, 2019
This is the first edition of the Italian translation of J.A. Schumpeter’s last conference. The intervention analyzes the relationship between institutional change and capitalism with particular reference to the United States after the Second World War ...
Adelino Zanini, Joseph Schumpeter
doaj   +1 more source

Quality Aspects In Institutional Translation: Introduction

, 2017
Introduction to the ...
Svoboda, Tomáš, Biel, Łucja, Łoboda, Krzysztof   +2 more
openaire   +2 more sources