Results 51 to 60 of about 128,473 (302)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Oñati Socio-Legal Series, 2014 This article will discuss how the current criminal policy of "drug war" waged in Brazil intensifies the various forms of violence to which women are subjected in a deeply unequal society.
Katie Silene Cáceres Arguello +1 more
doaj
Eastern European Transformation and Youth Attitudes toward Violence
International Journal of Conflict and Violence, 2011 This cross-national examination of the motives behind adolescent approval of violence in major cities in Germany and four Eastern European transformation societies (Czech Republic, Poland, Russia, Slovenia) draws on Institutional Anomie Theory (IAT ...
Eva Maria Groß, Berit Haußmann
doaj +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
Redress and civil litigation report [PDF]
, 2015 The Royal Commission has examined the extent to which ‘justice for victims’ of institutional child abuse has been, or can be, achieved through previous and current redress processes and civil litigation systems.
Royal Commission into Institutional Responses to Child Sexual Abuse
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Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Induced abortion, pregnancy loss and intimate partner violence in Tanzania: a population based study. [PDF]
, 2012 BACKGROUND: Violence by an intimate partner is increasingly recognized as an important public and reproductive health issue. The aim of this study is to investigate the extent to which physical and/or sexual intimate partner violence is associated with ...
Filippi, V. +16 more
core +1 more source
Grenfell, Austerity and Institutional Violence
, 2022 The complex chains of decisions that produce disasters like the Grenfell Tower fire are not readily described as ‘violence.’ ‘Violence’ is something that remains largely understood in popular consciousness, and in sociology, as an interpersonal ...
Cooper, Vickie +3 more
core +2 more sources
Universitas Humanística, 2014 Understanding of Institutional Knots in Addressing Domestic Violence Against Women: Contributions from a Feminist Interpretation to the Chilean Experience Abstract This article explores the limitations concerning an hegemonic conception of violence ...
Svenska Arensburg, Elizabeth Lewin
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source