Results 61 to 70 of about 128,473 (302)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Nations at arms. Public institutions, political violence, and civil society in the modern and contemporary Mezzogiorno

, 2023
This research project studies political violence and its institutional governance in Southern Italy from the independence of the Kingdom of Naples, in the first half of the 18th century, to the present day.
Laura Di Fiore
core  

Why Are Some Drug Markets More Violent than Others? An Analysis of Violence Using Fuzzy Logic

Social Sciences
Drug markets display varying levels of violence across urban contexts, and understanding the drivers behind these differences is essential for designing effective interventions.
Williams Gilberto Jiménez García, Daniel Sansó-Rubert   +1 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

INSTITUTIONAL RESPONSES TO SCHOOL VIOLENCE

Ra Ximhai, 2015
In order to prevent, attend to, mitigate, and punish school violence, diverse programs, actions, and laws have been created and implemented at the international, national, and state levels.
Emma Zapata Martelo, Rosalva Ruiz Ramírez   +1 more
doaj  

Democratización subnacional a la luz de los usos políticos del poder de policía del estado santiagueño durante el juarismo, 1995-2004

Nuevo mundo - Mundos Nuevos, 2012
This thesis analyzes the relationship between politics and violence in democracy and contrast to the particular uses and meanings of institutional violence present in the political practices of a political regime: the Juarismo in Santiago del Estero ...
Celeste Schnyder
doaj   +1 more source

The meaning of the social support network for women in situations of violence and breastfeeding

Revista Latino-Americana de Enfermagem, 2020
Objective: to understand the meanings attributed to the social support network of women breastfeeding and in situations of violence by an intimate partner.
Nayara Girardi Baraldi, Angelina Lettiere-Viana, Diene Monique Carlos, Natália Rejane Salim, Daniela Taysa Rodrigues Pimentel, Juliana Stefanello   +5 more
doaj   +3 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

P stones and provos : group violence in Northern Ireland and Chicago

, 2015
Although the government of the United States of America was established to protect the rights to life, liberty and the pursuit of happiness among all American citizens, this thesis argues intractable gang violence in inner-city Chicago has persistently ...
Ives-Allison, Nicole D.
core