Results 41 to 50 of about 4,667 (257)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Det nødvendige og det mulige. Aktuelle spændinger i dansk udenrigspolitik

open access: yesInternasjonal Politikk, 2018
Valget af Trump og Brexit indskriver sig sammen med Ruslands selvhævdende adfærd og Kinas øgede globale rolle i en udvikling, der set med danske udenrigspolitiske øjne opfattes som mere end almindeligt foruroligende: ”De tektoniske plader, som dansk ...
Louise Riis Andersen
doaj   +1 more source

Hvis krigen kommer

open access: yesKulturstudier, 2020
Artiklen undersøger produktionen af fremtid(er) i Hvis krigen kommer, udgivet af Statsministeriet og husstandsomdelt i januar 1962. Vores nærlæsning af pjecen tager udgangspunkt i begrebet „socio-tekniske forestillinger“, der søger at forene et blik for ...
Iben Bjørnsson   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Välfungerande institutioner och låg korruption mot the resource curse En fallstudie om Botswana och Sydsudan [PDF]

open access: yes, 2020
Flertal länder i subsahariska Afrika har drabbats av så kallade resursfällan, vilket går under namnet The Resource Curse (TRC). Teorin argumenterar för att detta känns igen genom stora mängder naturtillgångar och låg politisk och ekonomisk utveckling ...
Maroufi, Victoria
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Historisk udredning vedr. børn, unge og voksne anbragt i særforsorgens institutioner 1933-1980

open access: yes, 2022
Medlem af den af Social- og Indenrigsministeriet nedsatte kommission, under ledelse af Forsorgsmuseet, der skal lave en udredning af særforsorgens nyere historie med særlig henblik på børn, unge og voksne, der som følge af en anbringelse i sær- og ...
Petersen, Klaus; id_orcid   +4 more
core   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

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