Results 231 to 240 of about 1,478,008 (318)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

A foundation model for human-AI collaboration in medical literature mining. [PDF]

Nat Commun
Wang Z, Cao L, Jin Q, Chan J, Wan N, Afzali B, Cho HJ, Choi CI, Emamverdi M, Gill MK, Kim SH, Li Y, Liu Y, Luo Y, Ong H, Rousseau JF, Sheikh I, Wei JJ, Xu Z, Zallek CM, Kim K, Peng Y, Lu Z, Sun J.   +23 more
europepmc   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Replication of an Intervention to Mitigate Gender Bias in Student Evaluations of Teaching Yields Variable Results Across a Biology Department. [PDF]

CBE Life Sci Educ
Mitchem LD, Rupnow RL, Jaeger CP, Pezdek MN, Ganeng BKA, Samonds KE, Bergan-Roller HE.   +6 more
europepmc   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Working memory filtering at encoding and maintenance in healthy ageing, Alzheimer's and Parkinson's disease. [PDF]

Sci Rep
Toniolo S, Udale R, Klar VS, Maio MR, Attaallah B, Tofaris GK, Hu MT, Manohar SG, Husain M.   +8 more
europepmc   +1 more source

Design and Implementation of an Efficient Instruction Set for Ternary Processor

, 2013
Satish Narkhede, G. K. Kharate, Bharat S. Chaudhari   +2 more
openalex   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Can Structured Literacy Be a New Dimension for Interprofessional Practice Between Teachers and SLTs? Perceptions of Irish SLTs on Their Capacity and Practices in Supporting Children With Literacy Difficulties. [PDF]

Int J Lang Commun Disord
Kazmierczak-Murray S, Lehane P, Hannify C.   +2 more
europepmc   +1 more source