Results 61 to 70 of about 6,871,078 (322)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Enhancing a Near-Term Quantum Accelerator's Instruction Set Architecture for Materials Science Applications

IEEE Transactions on Quantum Engineering, 2020
Quantum computers with tens to hundreds of noisy qubits are being developed today. To be useful for real-world applications, we believe that these near-term systems cannot simply be scaled-down non-error-corrected versions of future fault-tolerant large ...
Xiang Zou, Shavindra P. Premaratne, M. Adriaan Rol, Sonika Johri, Viacheslav Ostroukh, David J. Michalak, Roman Caudillo, James S. Clarke, Leonardo DiCarlo, A. Y. Matsuura   +9 more
doaj   +1 more source

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Quantum compiling with a variational instruction set for accurate and fast quantum computing

Physical Review Research, 2023
The quantum instruction set (QIS) is defined as the quantum gates that are physically realizable by controlling the qubits in quantum hardware. Compiling quantum circuits into the product of the gates in a properly defined QIS is a fundamental step in ...
Ying Lu, Peng-Fei Zhou, Shao-Ming Fei, Shi-Ju Ran   +3 more
doaj   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

The RISC-V Instruction Set Manual. Volume 1: User-Level ISA, Version 2.0

, 2014
: RISC-V (pronounced risk-five) is a new instruction set architecture (ISA) that was originally designed to support computer architecture research and education, but which we now hope will become a standard open architecture for industry implementations.
Andrew Waterman, Yunsup Lee, D. Patterson, K. Asanovi   +3 more
semanticscholar   +1 more source

Dual-IS: Instruction Set Modality for Efficient Instruction Level Parallelism

, 2022
Exploiting instruction level parallelism (ILP) is a widely used method for increasing performance of processors. While traditional very long instruction word (VLIW) processors can exploit ILP energy-efficiently thanks to static instruction scheduling, they suffer from bad code density with serial parts that cannot utilize the multi-issue capabilities ...
Hepola, Kari, Multanen, Joonas, Jääskeläinen, Pekka   +2 more
openaire   +3 more sources

Randomized instruction set emulation [PDF]

ACM Transactions on Information and System Security, 2005
Injecting binary code into a running program is a common form of attack. Most defenses employ a “guard the doors” approach, blocking known mechanisms of code injection. Randomized instruction set emulation (RISE) is a complementary method of defense, one that performs a hidden randomization of an application's ...
Stephanie Forrest, David H. Ackley, Elena Gabriela Barrantes, Darko Stefanovic   +3 more
openaire   +2 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source