Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2015 Büyük bir hızla gelişen dünyada verimli yatırımların hayata geçirilebilmesi için yalnızca fizibilite ve teknik uygulamalar konularının değil planlama ve maliyet yönetimi çalışmalarının da önemi giderek artmaktadır.
Latif Onur UĞUR +2 more
doaj +6 more sources
Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application [PDF]
, 2016 Background The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in Type 1 Diabetes Mellitus.
A Trabucchi +95 more
core +5 more sources
Dissociating Explicit and Implicit Timing in Parkinson\u2019s Disease Patients: Evidence from Bisection and Foreperiod Tasks [PDF]
, 2018 A consistent body of literature reported that Parkinson\u2019s disease (PD) is marked by severe deficits in temporal processing. However, the exact nature of timing problems in PD patients is still elusive.
Capizzi, Mariagrazia +5 more
core +2 more sources
In vitro culture with gemcitabine augments death receptor and NKG2D ligand expression on tumour cells [PDF]
, 2019 Much effort has been made to try to understand the relationship between chemotherapeutic treatment of cancer and the immune system. Whereas much of that focus has been on the direct effect of chemotherapy drugs on immune cells and the release of antigens
A Ashkenazi +32 more
core +2 more sources
Every which way? On predicting tumor evolution using cancer progression models [PDF]
, 2019 Successful prediction of the likely paths of tumor progression is valuable for diagnostic, prognostic, and treatment purposes. Cancer progression models (CPMs) use cross-sectional samples to identify restrictions in the order of accumulation of driver ...
Díaz-Uriarte, Ramón, Vasallo, Claudia
core +2 more sources
Clinical test responses to different orthoptic exercise regimes in typical young adults [PDF]
, 2014 Purpose The relative efficiency of different eye exercise regimes is unclear, and in particular the influences of practice, placebo and the amount of effort required are rarely considered.
Horwood, Anna, Toor, Sonia
core +1 more source
PinAPL-Py: A comprehensive web-application for the analysis of CRISPR/Cas9 screens. [PDF]
, 2017 Large-scale genetic screens using CRISPR/Cas9 technology have emerged as a major tool for functional genomics. With its increased popularity, experimental biologists frequently acquire large sequencing datasets for which they often do not have an easy ...
Bath, Tyler +6 more
core +2 more sources
An enhanced CRISPR repressor for targeted mammalian gene regulation. [PDF]
, 2018 The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its utility.
Cecchi, Ryan J +20 more
core +1 more source
Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. [PDF]
, 2006 BackgroundSomatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined.
Albani, Salvatore +7 more
core +3 more sources
Protein disulfide-isomerase interacts with a substrate protein at all stages along its folding pathway [PDF]
, 2014 In contrast to molecular chaperones that couple protein folding to ATP hydrolysis, protein disulfide-isomerase (PDI) catalyzes protein folding coupled to formation of disulfide bonds (oxidative folding).
A Jansens +54 more
core +8 more sources