Results 21 to 30 of about 28,566 (150)

LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease. [PDF]

, 2019
The low-density lipoprotein receptor-related protein-1 (LRP1) has a dual role in the metabolism of the amyloid precursor protein (APP). In cellular models, LRP1 enhances amyloid-β (Aβ) generation via APP internalization and thus its amyloidogenic ...
Gordts, Philip LSM, Lechat, Benoit, Pietrzik, Claus U, Pradier, Laurent, Reekmans, Sara M, Roebroek, Anton JM, Storck, Steffen E, Van Gool, Bart   +7 more
core   +3 more sources

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Scenarios for applying RFID technology in construction project management [PDF]

, 2011
Radio Frequency Identification (RFID) technology has been widely applied in various areas such as retail, electronic transaction, logistic and supply chain management, scientific research, security, etc. It has brought about great benefits in these areas
Huang, GQ, Li, H, Lu, W
core   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Providing Diverse Trainees an Early and Transparent Introduction to Academic Appointment and Promotion Processes. [PDF]

, 2017
IntroductionThe growth in number of medical schools and increased numbers of faculty tracks have combined with evolving criteria for promotion to trigger a call for greater transparency of academic appointment and promotion processes.
Banks, Michael, Callahan, Edward J, Disbrow, Kenny, Medina, Jose, Soto-Greene, Maria, Sánchez, John P   +5 more
core   +1 more source

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

Advanced Science, EarlyView.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li, Xiangmin Tan, Yaran Liu, Yongquan He, Bo Yuan, Ping Wang, Guangzhi Ma, Mengzhe Guo, Jian Zhou, Qiang Sun   +9 more
wiley   +1 more source

Certified Organic Forests & Timber: the Hippocratic Opportunity [PDF]

, 2007
Organic farming was proposed in 1940 by Lord Northbourne as a response to chemical agriculture. Since then, organic agriculture has developed into an international A$50 billion industry with annual growth reported up to 30%.
Paull, John
core  

Racism and racial disparities in firearm violence: A scoping review

American Journal of Community Psychology, EarlyView.
Abstract Firearm violence (i.e., interpersonal, police firearm violence) disproportionately affects racially minoritized communities. Researchers recently shifted their focus from race to racism to better understand the factors that contribute to racial disparities in firearm violence.
Daniel B. Lee, Lexie M. Contreras, Laney Rupp, Stephanie H. Cook, Marc A. Zimmerman, Patrick M. Carter, Katherine P. Theall, Riley Bennett, Julia M. Fleckman   +8 more
wiley   +1 more source

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, EarlyView.
Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and posttranscriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron splicing ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Estimating process capability index Cpm using a bootstrap sequential sampling procedure

, 2010
Construction of a confidence interval for process capability index CPM is often based on a normal approximation with fixed sample size. In this article, we describe a different approach in constructing a fixed-width confidence interval for process ...
Aerts M., Castagliola P., Chan L. K., Chan L. K., Dantzig G. B., Efron B., Efron B., Ghosh M., Ghosh M., Gunter B. H., Gunter B. H., Gunter B. H., Gunter B. H., Hall P., Kotz S., L. Sandamali Dharmasena, Mukhopadhyay N., Mukhopadhyay N., Nanthakumar A., P. Castagliola, P. Zeephongsekul, Shao J., Silverman B. W., Stein C., Subbaiah P., Sullivan L. P., Swanepoel J. W. H., Vännman K., Vännman K.   +28 more
core   +1 more source