Büyük bir hızla gelişen dünyada verimli yatırımların hayata geçirilebilmesi için yalnızca fizibilite ve teknik uygulamalar konularının değil planlama ve maliyet yönetimi çalışmalarının da önemi giderek artmaktadır.
Latif Onur UĞUR +2 more
doaj +6 more sources
Dissociating Explicit and Implicit Timing in Parkinson\u2019s Disease Patients: Evidence from Bisection and Foreperiod Tasks [PDF]
A consistent body of literature reported that Parkinson\u2019s disease (PD) is marked by severe deficits in temporal processing. However, the exact nature of timing problems in PD patients is still elusive.
Capizzi, Mariagrazia +5 more
core +2 more sources
Identification of Class I HLA T Cell Control Epitopes for West Nile Virus [PDF]
The recent West Nile virus (WNV) outbreak in the United States underscores the importance of understanding human immune responses to this pathogen.
A Harari +56 more
core +7 more sources
In vitro culture with gemcitabine augments death receptor and NKG2D ligand expression on tumour cells [PDF]
Much effort has been made to try to understand the relationship between chemotherapeutic treatment of cancer and the immune system. Whereas much of that focus has been on the direct effect of chemotherapy drugs on immune cells and the release of antigens
A Ashkenazi +32 more
core +2 more sources
Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application [PDF]
Background The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in Type 1 Diabetes Mellitus.
A Trabucchi +95 more
core +5 more sources
Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth [PDF]
In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS),
Andreoli, Roberta +8 more
core +2 more sources
Identification of a Phosphorylation Site for Calcium/Calmodulindependent Protein Kinase II in the NR2B Subunit of the N-Methyl-D-aspartate Receptor [PDF]
The N-methyl-D-aspartate (NMDA) subtype of excitatory glutamate receptors plays critical roles in embryonic and adult synaptic plasticity in the central nervous system.
Alan J. Rosenstein +51 more
core +1 more source
Robotic ubiquitous cognitive ecology for smart homes [PDF]
Robotic ecologies are networks of heterogeneous robotic devices pervasively embedded in everyday environments, where they cooperate to perform complex tasks.
A Cesta +58 more
core +2 more sources
Computational methods reveal novel functionalities of PIWI-interacting RNAs in human papillomavirus-induced head and neck squamous cell carcinoma. [PDF]
Human papillomavirus (HPV) infection is the fastest growing cause of head and neck squamous cell carcinoma (HNSCC) today, but its role in malignant transformation remains unclear.
Califano, Joseph A +6 more
core +1 more source
Every which way? On predicting tumor evolution using cancer progression models [PDF]
Successful prediction of the likely paths of tumor progression is valuable for diagnostic, prognostic, and treatment purposes. Cancer progression models (CPMs) use cross-sectional samples to identify restrictions in the order of accumulation of driver ...
Díaz-Uriarte, Ramón, Vasallo, Claudia
core +2 more sources

