Results 101 to 110 of about 434,866 (360)
Does Working Longer Make People Healthier and Happier? [PDF]
PURPOSE: This study addresses the impact of late-life paid work on physical and psychological well-being. METHODS: Longitudinal data was drawn from the Health and Retirement Survey and the RAND-HRS data base for more than 6,000 individuals aged 59 to 69 ...
Calvo, Esteban
core +1 more source
Recognition of activities of daily living in natural “at home” scenario for assessment of Alzheimer's disease patients [PDF]
, 2015 In this paper we tackle the problem of Instrumental Activities of Daily Living (IADLs) recognition from wearable videos in a Home Clinical scenario. The aim of this research is to provide an accessible and yet detailed video-based navigation interface of
Benois-Pineau, Jenny +4 more
core +3 more sources
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
BMC GeriatricsIntroduction To assess the relationship between nutrition literacy (NL) and physical function limitations among Chinese older adults. Methods It was a cross-sectional survey carried out in May–July 2023, in Bengbu, China.
Yuhui Sun +3 more
doaj +1 more source
Evaluating Driving as a Valued Instrumental Activity of Daily Living
The American Journal of Occupational Therapy, 2011 Abstract The purpose of this translational research article is to illustrate how general practice occupational therapists have the skills and knowledge to address driving as a valued occupation using an algorithm based on the Occupational Therapy Practice Framework: Domain and Process (2nd ed.; American Occupational Therapy Association ...
Dickerson, Anne E. +3 more
openaire +4 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Frontiers in Public HealthIntroductionFunctional dependence on the performance of basic activities of daily living (ADLs) is associated with increased mortality. In this study, the Barthel index and its activities discriminate long-term mortality risk, and whether changes in this
Vicente Martín Moreno +16 more
doaj +1 more source
Utility of geriatric assessment to predict mortality in the oldest old: the Octabaix Study 3-year follow-up [PDF]
, 2016 Objective: Few studies have prospectively evaluated the utility of geriatric assessment tools as predictors of mortality in the oldest population. We investigated predictors of death in an oldest-old cohort after 3 years of follow-up.
Chivite, David +6 more
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source