Results 111 to 120 of about 434,866 (360)

The impact of a residential fire on occupational engagement and performance: A reflexive narrative approach

Burns Open
Residential fires are a devastating and stressful life event. The high number of residential fires per year and significant associated stressors impacts all aspects of daily life.
Gregory Chown
doaj   +1 more source

Self-Perception of Aging and Vulnerability to Adverse Outcomes at the Age of 65-70 Years [PDF]

, 2017
Objectives. This study examines the relationship between self-perception of aging and vulnerability to adverse outcomes in adults aged 65-70 years using data from a cohort of 1,422 participants in Lausanne, Switzerland. Methods.
Moser, Charlotte, Santos-Eggimann, Brigitte, Spagnoli, Jacques   +2 more
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Cognitive dysfunction, social participation, and performance of activities of daily living among a sub-urban community-dwelling older adults in Nigeria

Cogent Gerontology
Cognitive dysfunction (CF) in older adults significantly impacts activities of daily living (ADLs), social participation (SP), instrumental activities of daily living (IADLs), and overall quality of life. This cross-sectional study assessed CF, SP, ADLs,
Obiekwe Sochima Johnmark, Uzoamaka Nwakego Akobundu, Okwudili Precious Emuka, Akosile Christopher Olusanjo, Uchechukwu Martha Chukwuemeka, Ukamaka Gloria Mgbeojedo, Uchenna Prosper Okonkwo   +6 more
doaj   +1 more source

Analysis of health and longevity in oldest-old population: a health capital approach [PDF]

, 2005
Using 2002 cross-sectional data and 1998, 2000, 2002 three waves of panel data from the Chinese Longitudinal Healthy Longevity Survey, we study health in oldest old population.
Zhao, Zhong
core  

Test Your Memory-Spanish version (TYM-S):a validation study of a self-administered cognitive screening test [PDF]

, 2014
Artículo de publicación ISIObjectives: To develop the Test Your Memory (TYM)—Spanish version (TYM-S), a self-administered cognitive screening test, in a Chilean older sample and to estimate its psychometric properties and diagnostic accuracy. Methods:
Alegría, Araneda, Bland, Boustani, Brown, Cullen, Dubois, Evans, Fitzpatrick, Gifford, González-Hernández, Graham, Hancock, Hanley, Hanyu, Hughes, Lawton, Lezak, McKeith, McKhann, Merino, Morris, Muñoz, Muñoz-Neira, Muñoz-Neira, Nasreddine, Neary, Pfeffer, Prince, Reitz, Roman, Royall, Schalkwyk, Scharre, Szczesniak, Tangalos, Thies, Torralva, Villarejo, Winblad   +39 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Instrumental Activities of Daily Living Scales to Detect Cognitive Impairment and Dementia in Low- and Middle-Income Countries: A Systematic Review

, 2021
Heather Yemm, Louise Robinson, Stella‐Maria Paddick, Catherine Dotchin, M.L. Goodson, Alla Narytnyk, Marie Poole, Ríona Mc Ardle   +7 more
openalex   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source