Results 81 to 90 of about 879,103 (205)
Instrumental Variable Estimation with Heteroskedasticity and Many Instruments [PDF]
This paper gives a relatively simple, well behaved solution to the problem of many instruments in heteroskedastic data. Such settings are common in microeconometric applications where many instruments are used to improve efficiency and allowance for ...
Chao, Hausman, Newey, Swanson, Woutersen
core +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Exact computation of GMM estimators for instrumental variable quantile regression models
, 2017 We show that the generalized method of moments (GMM) estimation problem in instrumental variable quantile regression (IVQR) models can be equivalently formulated as a mixed integer quadratic programming problem.
Chen, Le-Yu, Lee, Sokbae
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
An Instrumental Variable for Non-ignorable Nonresponse
Harvard Data Science Review, 2023 Shiro Kuriwaki
doaj +1 more source
Bank concentration and non-performing loans in Central and Eastern European countries
Journal of Business Economics and Management, 2014 This paper examines the effect of bank concentration on the non-performing loans (NPLs) for ten Central and Eastern European (CEE) countries. The short-run effect of bank concentration is tested with the generalised method of moments system and the ...
Atilla Çifter
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Journal of Biostatistics and EpidemiologyThe genetic variant of interest is referred to be a weak instrumental variable in Mendelian randomization If the relevance assumption is not met. By and large, a weak instrument bias occurs when there is insufficient statistical evidence to support an ...
Danial Habibi +3 more
doaj +1 more source
HIV/AIDS pandemic and agricultural production in Cameroon
RUDN Journal of Economics, 2019 Whether HIV/AIDS affects agricultural production in Cameroon is purely an empirical issue due to controversy in results over the years. This study has as objectives to assess factors that affect the prevalence of HIV/AIDS and to explore the influence of ...
Mbu Daniel Tambi
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source