Results 101 to 110 of about 879,817 (289)

Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study

Microorganisms
Recent observational studies revealed an association between gut microbiota and aging, but whether gut microbiota are causally associated with the aging process remains unknown.
Chenglin Ye, Zhiqiang Li, Chun Ye, Li Yuan, Kailang Wu, Chengliang Zhu   +5 more
doaj   +1 more source

Predicting the Direction of Causal Effect Based on an Instrumental Variable Analysis: A Cautionary Tale

Journal of Causal Inference, 2016
An instrumental variable can be used to test the causal null hypothesis that an exposure has no causal effect on the outcome, by assessing the association between the instrumental variable and the outcome.
Burgess Stephen, Small Dylan S.
doaj   +1 more source

The Instrumental Weighted Variables. Part II. Square root of n-consistency [PDF]

The definition of Instrumental Weighted Variables (IWV) (which is a robust version of the classical Instrumental Variables) and conditions for the weak consistency as given in the Part I of this paper are recalled.
Jan Ámos Víšek
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

ASIAN DEMOGRAPHIC TRANSITION: AN INSTRUMENTAL-VARIABLES PANEL APPROACH [PDF]

We examine patterns in fertility during the demographic transition using a panel data set across 25 Asian countries for 1975-2003. The adult female literacy rate is used as an instrumental variable for the endogenous female labor force participation rate,
Michael P. Shields, Sang-Young Rhyu, Yongil Jeon   +2 more
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Understanding Instrumental Variables in Models with Essential Heterogeneity [PDF]

This paper examines the properties of instrumental variables (IV) applied to models with essential heterogeneity, that is, models where responses to interventions are heterogeneous and agents adopt treatments (participate in programs) with at least ...
Edward Vytlacil, James J. Heckman, Sergio Urzua   +2 more
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Evaluation and validation of social and psychological markers in randomised trials of complex interventions in mental health: a methodological research programme

Health Technology Assessment, 2015
Background: The development of the capability and capacity to evaluate the outcomes of trials of complex interventions is a key priority of the National Institute for Health Research (NIHR) and the Medical Research Council (MRC).
Graham Dunn, Richard Emsley, Hanhua Liu, Sabine Landau, Jonathan Green, Ian White, Andrew Pickles   +6 more
doaj   +1 more source

Specification Testing in Panel Data With Instrumental Variables [PDF]

This paper shows a convenient way to test whether instrumental variables are correlated with individual effects in a panel data set. It shows that the correlated fixed effects specification tests developed by Hausman and Taylor (1981) extend in an ...
Gilbert E. Metcalf
core