Results 231 to 240 of about 7,203,866 (304)

Peptide-based therapeutics targeting GPCRs: recent applications in the treatment of metabolic disorders. [PDF]

Front Pharmacol
Di Martino S, De Rosa M.
europepmc   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

Factors influencing insulin prescribing practices among small animal specialists. [PDF]

Front Vet Sci
DeRogatis NE, McCool KE, Donnell CE, Lynch AM, Birkenheuer AJ.   +4 more
europepmc   +1 more source

Asymmetric Structure‐Driven Functional Synergy: A Multistimuli‐Activated Janus Nanomotor for Self‐Amplifying NO Cascade Therapy

Advanced Science, EarlyView.
The Janus nanomotors leverage an “asymmetric structure‐driven functional synergy” strategy to orchestrate spatiotemporally coordinated catalytic functions, in situ self‐amplifying NO generation, and deep tumor penetration, thereby enabling controllable, sustained, and uniform NO generation within the tumor microenvironment.
Chengcheng Li, Yu Zhang, Yu Chen, Lingyun He, Xian Shen, Weijian Sun, Hongbo Zhang   +6 more
wiley   +1 more source

A Novel <i>ABCC8</i> Variant in an Adult with Hyperinsulinemic Hypoglycemia Suggestive of Congenital Hyperinsulinism: A Case Report. [PDF]

Reports (MDPI)
Rabani H, Rosenblat I, Osman K, Shalata A, Saiegh L.   +4 more
europepmc   +1 more source

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

Early versus late initiation of long-acting insulin in paediatric and adult diabetic ketoacidosis: A systematic review and meta-analysis of randomised control trials. [PDF]

Diabetes Obes Metab
Nguyen B, Quon S, Dhaliwal B, Warwas M, Stafford S.   +4 more
europepmc   +1 more source

Acupuncture May Reduce Insulin Doses in Overweight Insulin-Treated Patients With Type 2 Diabetes Mellitus: A Crossover Randomized Controlled Pilot Trial. [PDF]

Diabetes Obes Metab
Milia A, Silverii GA, Cortoni L, Monami M, Limatola V, Mannucci E.   +5 more
europepmc   +1 more source

Clinical Consequences of Inadvertent Intramuscular Administration of Subcutaneous Risperidone Formulation. [PDF]

Case Rep Psychiatry
Ashley E, Aalomerovic A, Blackmer K, El-Mallakh RS.   +3 more
europepmc   +1 more source

Analysis of differences in response to long-acting growth hormone therapy and influencing factors between patients with idiopathic short stature (ISS) and growth hormone deficiency (GHD). [PDF]

Transl Pediatr
Tang F, Yan L, Gou P, Li Z, Cheng X.
europepmc   +1 more source