Diabetic Ketoacidosis Updates: Titratable Insulin Infusions and Long-Acting Insulin Early [PDF]
Critical Care Research and Practice, 2021 Background. To compare a titratable insulin infusion order set (vs. nontitratable) and early administration of long-acting insulin in adult patients with diabetic ketoacidosis (DKA). Methods.
Justin Kinney +2 more
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Di-PEGylated insulin: A long-acting insulin conjugate with superior safety in reducing hypoglycemic events [PDF]
Acta Pharmaceutica Sinica BAlthough the discovery of insulin 100 years ago revolutionized the treatment of diabetes, its therapeutic potential is compromised by its short half-life and narrow therapeutic index.
Zhipeng Zeng +7 more
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Effects of Ultra-Long-Acting Insulin Compared to Long-Acting Insulin on Diabetic Ketoacidosis Incidence in Type 1 Diabetes Mellitus Patients [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2022 Wafa A Alsofiani,1 Bandar H Alessa,2 Fahad Alsabaan,3 Abdullah U Althemery,4 Aliah M Ghith,3 Abdullah A Alfaifi4 1Family Medicine and Diabetes Center, Prince Mansour Hospital, Taif, Saudi Arabia; 2Family Medicine Department, National Guard Hospital ...
Alsofiani WA +5 more
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Association between industry payments and prescriptions of long-acting insulin: An observational study with propensity score matching. [PDF]
PLoS Medicine, 2021 BackgroundThe rapidly increased spending on insulin is a major public health issue in the United States. Industry marketing might be one of the upstream determinants of physicians' prescription of long-acting insulin-the most commonly used and costly ...
Kosuke Inoue +3 more
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Assessment of the use of long-acting insulin in management of diabetic ketoacidosis in pediatric patients: a randomized controlled trial [PDF]
Annals of Pediatric Endocrinology & MetabolismPurpose We evaluated the effectiveness of early start of long-acting insulin during management of diabetic ketoacidosis (DKA) in pediatric patients. Methods Patients with DKA were randomly assigned to receive either a traditional DKA management protocol ...
Amany El Hawary +4 more
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A cost-utility analysis of long-acting insulin analogues (detemir, glargine and degludec) for the treatment of adult type 1 diabetes in South Africa [PDF]
Cost Effectiveness and Resource AllocationBackground Type 1 Diabetes Mellitus (T1DM) is a life-threatening condition that is managed with administered insulin. Intermediate- to long-acting insulin represents the basal insulin constituent of the total insulin used in treating T1DM.
Mark T. Verryn, Susan Cleary
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The Current Situation Regarding Long-Acting Insulin Analogues Including Biosimilars Among African, Asian, European, and South American Countries; Findings and Implications for the Future [PDF]
Frontiers in Public Health, 2021 Background: Diabetes mellitus rates continue to rise, which coupled with increasing costs of associated complications has appreciably increased global expenditure in recent years. The risk of complications are enhanced by poor glycaemic control including
Brian Godman +88 more
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Design of a novel long-acting insulin analogs by acetylation modification and compared with insulin Icodec [PDF]
Scientific ReportsInsulin is a potent medication for managing diabetes, yet its short half-life requires daily administration. Currently, Novo Nordisk’s icodec is the sole insulin available on the market that requires administration only once a week.
Min Yu +6 more
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Effects of intranasal long-acting insulin pretreatment on postoperative delirium and the NLRP3/caspase-1/IL-1β pathway in older patients with esophageal cancer [PDF]
Inflammation and RegenerationBackground Insulin exhibits neuroprotective and anti-inflammatory properties. Preoperative intranasal insulin preconditioning is a potential strategy to prevent postoperative delirium (POD), but prior studies mainly used rapid-acting formulations.
Yong Zhang +5 more
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Long-acting insulin allergy in a diabetic child [PDF]
International Journal of Immunopathology and Pharmacology, 2017 Insulin allergy has been uncommon since the introduction of human recombinant insulin preparations; the prevalence is 2.4%. Insulin injection could elicit immediate reactions, which are usually induced by an IgE-mediated mechanism, within the first hour ...
Carla Mastrorilli +5 more
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