Results 81 to 90 of about 7,203,866 (304)

The modification of insulin to enhance oral delivery systems [PDF]

, 2009
textWhile a number of PEGylated proteins have been studied for injectable applications and reviewers have used this data to speculate possible oral delivery improvements, a detailed investigation of PEGylated insulin for oral delivery and the development
Kanzelberger, Melissa Ann
core  

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Design of a novel long-acting insulin analogs by acetylation modification and compared with insulin Icodec

Scientific Reports
Insulin is a potent medication for managing diabetes, yet its short half-life requires daily administration. Currently, Novo Nordisk’s icodec is the sole insulin available on the market that requires administration only once a week.
Min Yu, Chuanzhi Zhang, Hongjiang Xu, Yuanzhen Dong, Hongxiang Zhu, Chunguang Xia, Jun Feng   +6 more
doaj   +1 more source

Budget Impact of Long-Acting Insulin Analogues: The Case in Brazil.

PLoS ONE, 2016
BackgroundLong-acting insulin analogues for type 1 diabetes (T1D) treatment have been available on the Brazilian market since 2002. However, the population cannot access the analogues through the public health system.ObjectiveTo estimate the incremental ...
Fernanda O Laranjeira, Everton Nunes da Silva, Maurício G Pereira   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Correlation in Dose-Response to Rapid- and Long-Acting Insulin for People with Type 1 Diabetes

, 2022
In diabetes, it can become necessary to switch between pump- and pen-based insulin treatment. This switch involves a translation between rapid- and long-acting insulin analogues.
Bengtsson, Henrik, Engell, Sarah Ellinor, Jørgensen, John Bagterp, Aradóttir, Tinna Björk   +3 more
core   +1 more source

Rebound ketoacidosis in a patient with diabetic ketoacidosis using ultra-long-acting insulin

Journal of Clinical and Translational Endocrinology Case Reports
Background/objective: A 26-year-old Taiwanese woman with type 1 diabetes mellitus developed diabetic ketoacidosis after missing a premixed insulin dose.
Hsin-I Chi, Ye-Fong Du
doaj   +1 more source

Insulin analogues versus human insulin in type 1 diabetes: direct and indirect meta-analyses of efficacy and safety

Brazilian Journal of Pharmaceutical Sciences, 2013
All patients with Diabetes Mellitus (DM) receive insulin therapy. In this study, we evaluated the efficacy, safety and tolerability of human insulin and insulin analogues.
Andréia Cristina Conegero Sanches, Cassyano Januário Correr, Rafael Venson, Patrícia Rodrigues Gonçalves, Mariana Martins Garcia, Mário Sérgio Piantavini, Roberto Pontarolo   +6 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

High-mix insulins

Indian Journal of Endocrinology and Metabolism, 2015
Premix insulins are commonly used insulin preparations, which are available in varying ratios of different molecules. These drugs contain one short- or rapid-acting, and one intermediate- or long-acting insulin. High-mix insulins are mixtures of insulins
Sanjay Kalra, Mohammad Hamed Farooqi, Ali E El-Houni   +2 more
doaj   +1 more source