Results 301 to 310 of about 422,814 (354)

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Retraction Note: Insulin-Like Growth Factor Binding Protein-Related Protein 1 Activates Primary Hepatic Stellate Cells via Autophagy Regulated by the PI3K/Akt/mTOR Signaling Pathway. [PDF]

Dig Dis Sci
Zhou Y, Zhang Q, Kong Y, Guo X, Zhang H, Fan H, Liu L.   +6 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Insulin-like growth factor binding protein proteolysis

Trends in Endocrinology & Metabolism, 2003
High-affinity interactions between insulin-like growth factors (IGF-I and IGF-II) and insulin-like growth factor-binding proteins (IGFBP-1, -2, -3, -4, -5 and -6) antagonize the binding of IGF to the type 1 IGF receptor. Proteases found in a variety of biological fluids can degrade IGFBP 1-6 into fragments that have a greatly reduced affinity for IGF-I
R Clay, Bunn, John L, Fowlkes
openaire   +2 more sources

Phosphorylation of insulin-like growth factor binding proteins

Molecular and Cellular Endocrinology, 1997
Insulin-like growth factor (IGF) binding proteins (IGFBPs) play a key role in regulating the availability of IGFs in the circulation and the extracellular environment. Three of these proteins-IGFBP-1, IGFBP-3 and IGFBP-5-are known to be serine-phosphorylated in their central domains, and the others have possible target sites for serine/threonine ...
J A, Coverley, R C, Baxter
openaire   +2 more sources

Insulin‐like growth factor‐binding protein 1 and insulin‐like growth factor‐binding protein 3 in pre‐eclampsia

BJOG: An International Journal of Obstetrics & Gynaecology, 1996
Objective To investigate circulating levels of insulin‐like growth factor‐binding protein 1 (IGFBP‐1) and IGFBP‐3 in the mother and the fetus in pregnancies complicated by pre‐eclampsia, and the relationship between serum levels of IGFBPs and fetal birthweight.Design A prospective study over an 18 month period.Setting A tertiary care ...
H S, Wang, J D, Lee, B J, Cheng, Y K, Soong   +3 more
openaire   +2 more sources

Insulin-Like Growth Factor-Binding Proteins and Ovarian Folliculogenesis

Hormone Research, 1996
In the ovary, insulin-like growth factors (IGFs) enhance both proliferation and differentiation of follicular cells by potentiating gonadotropin's actions. The biological effects of IGFs are strikingly modulated by IGF-binding proteins (IGFBPs), whose levels in follicular fluid dramatically change during folliculogenesis.
Monget, Philippe, Besnard, N., Huet, Camille, Pisselet, C., Monniaux, Danielle   +4 more
openaire   +3 more sources

Insulin-like Growth Factor Binding Proteins in Development

2005
IGFBPs regulate growth and development by regulating IGF transport to tissues and IGF bioavailability to IGF receptors at cell membrane level. IGFBP excess leads predominantly to inhibition of IGF action and growth retardation with impaired organogenesis. Absence of human and also mouse ALS leads to decreased IGF-I levels in circulation and causes mild
Josef V, Silha, Liam J, Murphy
openaire   +2 more sources

Colocalization of insulin-like growth factor-binding protein with insulin-like growth factor I

American Journal of Physiology-Renal Physiology, 1991
We report the localization of insulin-like growth factor I (IGF-I) and a 25-kDa form of insulin-like growth factor-binding protein (IGF-BP-1) in adult rat kidney. The antigens were localized using a rabbit anti-human IGF-I antibody, and a rabbit anti-human IGF-BP-1 antibody raised against human 25-kDa IGF-BP-1 purified from amniotic fluid ...
S, Kobayashi, D R, Clemmons, M A, Venkatachalam   +2 more
openaire   +2 more sources

Insulin-like growth factor binding proteins 4-6

Best Practice & Research Clinical Endocrinology & Metabolism, 2015
Insulin-like growth factor binding proteins (IGFBPs) 4-6 have important roles as modulators of IGF actions. IGFBP-4 and IGFBP-6 predominantly inhibit IGF actions, whereas IGFBP-5 may enhance these actions under some circumstances. IGFBP-6 is unique among the IGFBPs for its marked IGF-II binding preference.
openaire   +2 more sources

Insulin-like growth factor binding protein (IGFBP) signalling

Growth Hormone & IGF Research, 2004
Insulin-like growth factor-I and -II (IGF-I and -II) are peptides that regulate cell metabolism, growth, differentiation and survival according to physiological requirements and the tissue type involved. They bind to two transmembrane receptors, the type I and type II IGF receptors (IGF-IR and IGF-IIR), although their cellular action is mediated via ...
openaire   +2 more sources