Results 321 to 330 of about 422,814 (354)

The Role of Insulin-Like Growth Factor Binding Proteins

Neuroendocrinology, 2006
Insulin-like growth factors (IGFs) are fundamental cell regulators with an evolutionary conserved role synchronising tissue growth, development and function according to metabolic conditions. Although structurally very similar to insulin, the IGFs act in a very different way as cell regulators. Whereas insulin is stored in a specific gland and released
Perks, Claire, Holly, Jeffrey M P
openaire   +3 more sources

Regulatory Actions of Insulin-like Growth Factor-binding Proteins

Trends in Endocrinology & Metabolism, 1998
The six insulin-like growth factor-binding proteins (IGFBPs) are important regulators of insulin-like growth factor (IGF) action. Circulating high molecular weight complexes that contain IGF and IGFBP-3 restrict IGF bioavailability, and excess IGFBPs inhibit IGF action by forming biologically inactive complexes.
M M, Rechler, D R, Clemmons
openaire   +2 more sources

General aspects of insulin-like growth factor binding proteins

Endocrine, 1997
Insulin-like growth factor binding proteins (IGFBPs) belong to a family of at least six homologous proteins that bind insulin-like growth factors (IGFs) and modulate many of their biological actions. IGFBPs are produced by a wide variety of tissues and their circulating levels are regulated by both hormonal and metabolic factors.
K, Chan, E M, Spencer
openaire   +2 more sources

Insulin-Like Growth Factor Binding Protein-3

1994
In plasma and other biological fluids insulinlike growth factors are bound to a family of structurally homologous binding proteins (IGFBPs).
openaire   +1 more source

Insulin-like growth factor binding-protein-3 (IGFBP–3)

Best Practice & Research Clinical Endocrinology & Metabolism, 2015
The IGF system comprises two IGFs (IGF-1, IGF-2), two IGF-receptors (IGF-R1, IGF-R2), and six IGF binding proteins (IGFBPs) with a high affinity for IGFs. The IGFBPs, of which IGFBP-3 is the most abundant in postnatal blood, link with IGFs and prevent them from being degraded; they also facilitate IGF transport through body compartments.
openaire   +2 more sources

Insulin-Like Growth Factor Binding Protein-1

1994
IGFBP-I is a 25.3 kDa protein and is one of 6 structurally related proteins which bind and modulate the bioactivity of IGF-I and IGF-II. It is synthesized primarily in the liver and decidualized uterine endometrium, and is distributed primarily in the intravascular space and lymph.
openaire   +1 more source

Insulin-like growth factor-binding proteins and bone metabolism

American Journal of Physiology-Endocrinology and Metabolism, 2008
Insulin-like growth factor-binding proteins (IGFBPs) are important regulators of bone metabolism. However, their precise roles are not fully understood, since IGFBPs can have both enhancing and inhibiting effects on IGF action, depending on context and posttranslational modifications, as well as IGF-independent effects.
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The insulin-like growth factor-binding protein superfamily

Growth Hormone & IGF Research, 2000
R G, Rosenfeld, V, Hwa, E, Wilson, S R, Plymate, Y, Oh   +4 more
openaire   +2 more sources

Cancer treatment and survivorship statistics, 2022

Ca-A Cancer Journal for Clinicians, 2022
Kimberly D Miller, Leticia M Nogueira, Angela B Mariotto   +2 more
exaly  

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly