Results 71 to 80 of about 14,817,072 (278)

The GH-IGF-I axis and breast cancer [PDF]

, 2012
MD (Res)Breast cancer remains one of the most common causes of death amongst women today. Worldwide approximately 1.3 million women are diagnosed as having breast cancer every year.
Laban, Christiana
core   +4 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Molecular networks in FGF signaling: Flotillin-1 and Cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2 [PDF]

, 2012
Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Traub Stephanie, Tomasovic, Ana, Stephanie Traub, Ana Tomasovic, Ana Tomasovic (189773), Ritva Tikkanen (189783), Tikkanen Ritva, Tikkanen, Ritva, Traub, Stephanie, Tomasovic Ana, Ritva Tikkanen, Stephanie Traub (189777)   +11 more
core   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

MiR-205 serves as a prognostic factor and suppresses proliferation and invasion by targeting insulin-like growth factor receptor 1 in human cervical cancer

Tumor Biology, 2017
MicroRNAs are a kind of small and non-coding RNAs, which have been demonstrated to play an important role in the progression of human cervical cancer.
Hui Pang, Xiuying Yue
doaj   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Human adaptation to high altitude: a review of convergence between genomic and proteomic signatures

Human Genomics, 2022
Both genomics- and proteomics-based investigations have identified several essential genes, proteins, and pathways that may facilitate human adaptive genotype/phenotype in a population-specific manner.
Vandana Sharma, Rajeev Varshney, Niroj Kumar Sethy   +2 more
doaj   +1 more source

Plasma Proteomic Signatures of Left Atrial Dysfunction and Cerebral Small Vessel Disease

JACC: Basic to Translational Science
Reduced left atrial (LA) strain is associated with cerebral small vessel disease (CSVD). In memory clinic patients without atrial fibrillation, LA reservoir strain and LA conduit strain were significantly associated with white matter hyperintensity ...
Eugene S.J. Tan, MBBS, Ming Ann Sim, MBBS, Hyungwon Choi, PhD, Siew Pang Chan, PhD, Vera Yuan Cai, MD, PhD, Lingli Gong, MD, Narayanaswamy Venketasubramanian, MD, Boon-Yeow Tan, MBBS, Saima Hilal, MD, PhD, Mitchell K.P. Lai, PhD, Lieng-Hsi Ling, MD, A. Mark Richards, MD, PhD, Christopher Chen, MD   +12 more
doaj   +1 more source

Somatotropic Axis Regulation Unravels the Differential Effects of Nutritional and Environmental Factors in Growth Performance of Marine Farmed Fishes

Frontiers in Endocrinology, 2018
The Gh/Prl/Sl family has evolved differentially through evolution, resulting in varying relationships between the somatotropic axis and growth rates within and across fish species. This is due to a wide range of endogenous and exogenous factors that make
Jaume Pérez-Sánchez, Paula Simó-Mirabet, Fernando Naya-Català, Juan Antonio Martos-Sitcha, Erick Perera, Azucena Bermejo-Nogales, Laura Benedito-Palos, Josep Alvar Calduch-Giner   +7 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source