Results 161 to 170 of about 39,607,185 (297)

Effects of Diet on Levels of Bone Mineral Density and Serum Insulin-Like Growth Factor-1 - Original Investigation

open access: yes, 2006
Osteoporosis is a major public health problem and the role of diet in both its prevention and pathogenesis is currently investigating. Diet is a modifiable factor which has role on both bone mass formation and prevention of osteoporosis.
Merih Eryavuz Sarıdoğan   +3 more
core  

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

open access: yesAdvanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li   +9 more
wiley   +1 more source

Effects of early administration of insulin-like growth factor-1 on cognitive function in septic encephalopathy

open access: yes, 2019
Yang Yang,1,* Shengru Liang,2,* Yuqian Li,1,* Fei Gao,1 Yuan Cao,3 Xiaoyu Zhao,4 Guodong Gao,1 Lihong Li1 1Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi’an, Shaanxi Province 710038, China; 2Department of ...
Liang S   +7 more
core  

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

open access: yesAdvanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li   +8 more
wiley   +1 more source

Roles of insulin-like growth factor 1 receptor in growth regulation in 15q26 deletion and duplication syndrome. [PDF]

open access: yesBiomed Rep
Yu K   +14 more
europepmc   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

open access: yesAdvanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon   +6 more
wiley   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

open access: yesAdvanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy