Results 61 to 70 of about 498,256 (338)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Niveles séricos de los factores de crecimiento similares a la insulina I y II y su proteína 3 de enlace en mujeres con lesiones escamosas intraepiteliales y cáncer de cuello uterino

Biomédica: revista del Instituto Nacional de Salud, 2006
Introducción. La citología cervico-uterina como prueba de tamizaje del cáncer cervical tiene limitaciones. Un marcador que permita identificar mujeres en riesgo de desarrollar este cáncer sería de utilidad para prevenir el desarrollo de esta enfermedad ...
Martha Lucía Serrano, Alfredo Romero, Ricardo Cendales, Myriam Sánchez Gómez, María Mercedes Bravo   +4 more
doaj   +1 more source

Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]

, 2013
Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba, Csont, Tamás Bálint, Fekete, Veronika, Ferdinandy, Péter, Gyémánt, Nóra, Kocsis-Fodor, Gabriella, Pipis, Judit, Puskás, László, Szűcs, Gergő, Sárközy, Márta, Zvara, Ágnes   +10 more
core   +3 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Evaluation of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 Expression Levels in Patients with Chronic Lymphocytic Leukemia

Turkish Journal of Hematology, 2016
Objective: Chronic lymphocytic leukemia (CLL) is a disease of nonproliferating and mature-appearing B lymphocytes. Insulin-like growth factor-1 (IGF-1) is a small peptide hormone and has mitogenic and antiapoptotic effects, and insulin-like growth ...
Mesut Ayer, Abdullah Sakin, Selim Ay, Aylin Ayer, Elif Gökçen Sazak, Melih Aktan   +5 more
doaj   +1 more source

Association of Growth Velocity with Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Children with a Vegan Diet

Journal of Biomedicine and Translational Research, 2020
Background: The vegan diet in children provides the benefit of reducing the risk of being overweight and improving the fat profile. The risk that can occur in the provision of a vegan diet in children is anthropometric size below reference and low ...
Arie Purwana, Budiono Budiono, Jose RL Batubara, Muhammad Faizi   +3 more
doaj   +1 more source

Insulin-like Growth Factor-binding Protein-3 Modulates Expression of Bax and Bcl-2 and Potentiates p53-independent Radiation-induced Apoptosis in Human Breast Cancer Cells*

Journal of Biological Chemistry, 2000
We report that transfection of insulin-like growth factor-binding protein-3 (IGFBP-3) cDNA in human breast cancer cell lines expressing either mutant p53 (T47D) or wild-type p53 (MCF-7) induces apoptosis. IGFBP-3 also increases the ratio of pro-apoptotic
A. Butt, S. Firth, M. King, R. Baxter
semanticscholar   +1 more source

Developmental pattern of fetal growth hormone, insulin-like growth factor I, growth hormone binding protein and insulin-like growth factor binding protein-3 [PDF]

Archives of Disease in Childhood - Fetal and Neonatal Edition, 1997
AIMS To evaluate the developmental pattern of fetal growth hormone (GH), insulin-like growth factor I (IGF-I), GH binding protein (GHBP) and IGF binding protein-3 (IGF-3); to determine the implications for fetal growth. METHODS Serum GH, IGF-I, GHBP
P, Pirazzoli, E, Cacciari, R, De Iasio, M C, Pittalis, P, Dallacasa, S, Zucchini, S, Gualandi, S, Salardi, C, David, S, Boschi   +9 more
openaire   +2 more sources

Differential interactions between IGFBP-3 and transforming growth factor-beta (TGF-β) in normal vs cancerous breast epithelial cells [PDF]

In addition to modulating insulin-like growth factors action, it is now clear that insulin-like growth factor-binding protein-3 also has intrinsic effects on cell growth and survival.
AC Williams, AD Hollowood, AD Hollowood, AM Taylor, CA Fowler, CM Perks, CM Perks, CM Perks, CM Perks, CW Daniel, HD Soule, JI Jones, JL Martin, KL Schmeichel, KW Colston, LI Gold, M Reiss, MA Chrenek, ME Yateman, P Cohen, R Rajah, S Fanayan, S Kansra, SC Davies, SM Leal, Y Oh, Y Oh, Y Oh, Z Pietrzkowski, ZP Gill   +29 more
core   +2 more sources

Characterization of Mouse Tissue Kallikrein 5 [PDF]

, 2006
Mouse tissue kallikreins (Klks) are members of a large, multigene family consisting of 37 genes, 26 of which can code for functional proteins. Mouse tissue kallikrein 5 (KIk5) has long been thought to be one of these functional genes, but the gene ...
Atsushi Kimura, Barrett A. J., Katsueki Ogiwara, Kensaku Hirata, Noriko Yamano, Sanath Rajapakse, Sumio Takahashi, Takayuki Takahashi   +7 more
core   +1 more source