Results 81 to 90 of about 31,695,425 (269)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Insulin-like growth factor binding protein-3 in preterm infants with retinopathy of prematurity

Indian Journal of Ophthalmology, 2012
Background: Retinopathy of prematurity (ROP) is the main cause of visual impairment in preterm newborn infants. Objective: This study was conducted to determine whether insulin-like growth factor binding protein -3 (IGFBP-3) is associated with ...
Manizheh Mostafa Gharehbaghi, Ali Peirovifar, Karim Sadeghi, Haleh Mostafidi   +3 more
doaj   +1 more source

Synergistic and antagonistic effects of TNF-[alpha] and IGF-I in heart failure : "in vitro" and "in vivo" study of cardiac and skeletal muscle [PDF]

, 2006
Cardiovascular diseases are a major cause of morbidity and mortality in industrialized countries. All forms of myocardial injury first lead to compensatory hypertrophy, which eventually progresses to heart failure.
Murigande, Claire
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Single nucleotide polymorphism in Egyptian cattle insulin-like growth factor binding protein-3 gene

Journal of Genetic Engineering and Biotechnology, 2014
Insulin-like growth factor binding protein-3 (IGFBP-3) gene is a structural gene responsible for the multiple influences of insulin-like growth factors (IGFs) system. It is considered as a candidate gene for growth and production traits.
Othman E. Othman, Sally S. Alam, Sekena H. Abd El-Aziem   +2 more
doaj   +1 more source

Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk [PDF]

, 2010
Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor proteins, the SH2B proteins.
Linda Partridge, Partridge, L., Withers, D., Stocker, H, Withers, D.J., Foley, A., Foley, Andrea, Hafen, Ernst, Cathy Slack, Thornton, Janet M., Werz, C, Wieser, D, Stocker, Hugo, Thornton, J., Slack, C, Wieser, D., Werz, C., Hafen, E, Withers, Dominic J., Hafen, E., Lu, Bingwei, Dominic J Withers, Nazif Alic, Janet M Thornton, Werz, Christian, Alic, N, Stocker, H., Withers, DJ, Ernst Hafen, Partridge, Linda, Slack, Cathy, Hugo Stocker, Andrea Foley, Wieser, Daniela, Foley, A, Alic, Nazif, Partridge, L, Christian Werz, Thornton, JM, Alic, N., Daniela Wieser, Slack, C., Lu, B., Thornton, J. M.   +43 more
core   +1 more source

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

Effects of 8 Weeks of Resistance Training and IGF-1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats

Medical Laboratory Journal, 2017
Background and Objectives: We studied effects of eight weeks of resistance training and IGF-1 injection on serum level of IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio in Wistar rats.
Babisan Askari, Nahid Bijeh, Amir Rashid Lamir   +2 more
doaj  

Glucokinase links Kruppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease [PDF]

, 2011
The polymorphism, KLF6-IVS1-27A, in the Krüppel-like factor 6 (KLF6) transcription factor gene enhances its splicing into antagonistic isoforms and is associated with delayed histological progression of nonalcoholic fatty liver disease (NAFLD).
Gastaldelli, Amalia, Lee, Y., Isabel Fiel, Elisabetta Bugianesi, Miele, L., Lee, U., Bugianesi, E., Emma Buzzigoli, Andrea Mari, Pascoe, L., Mark Walker, Christopher P. Day, Burt, Alastair D., Walker, M., Bechmann, L., Hui, Kei Y, Fiel, I., Buzzigoli, E., Bechmann, Lars P., Miele, Luca, Fiel, Isabel., Luca Miele, Mari, Andrea, Patman, G., Ursula Muñoz, Day, Christopher P., Vetter, Diana., Burt, A., Lee, Young-Min., Munoz, Ursula., Hannivoort, Rebekka A., Alastair D. Burt, Amalia Gastaldelli, Walker, Mark., Agius, Loranne, Mari, A., Agius, Loranne., et al., Buzzigoli, Emma, Walker, Mark, Loranne Agius, Scott L. Friedman, Lee, Young-Min, Pascoe, Laura., Miele, Luca., Munoz, Ursula, Hui, K., Day, C., Laura Pascoe, Pascoe, Laura, Gastaldelli, Amalia., Fiel, Isabel, Ursula E. Lee, Gillian L. Patman, Munoz, U., Kei Y. Hui, Agius, L., Mari, Andrea., Vetter, D., Demetrio Ciociaro, Ciociaro, D., Buzzigoli, Emma., Lars P. Bechmann, Helen L. Reeves, Patman, Gillian L., Hannivoort, Rebekka A ., Ciociaro, Demetrio, Ciociaro, Demetrio., Mu?oz, Ursula, Bugianesi, Elisabetta, Diana Vetter, Reeves, Helen L., Hannivoort, R., Lee, Ursula E., Rebekka A. Hannivoort, Bugianesi, Elisabetta., Young-Min Lee, Vetter, Diana, Hui, Kei Y., Friedman, Scott L., Gastaldelli, A.   +80 more
core   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source