Results 41 to 50 of about 405,429 (298)

IGFBP-3 inhibits Wnt signaling in metastatic melanoma cells. [PDF]

, 2016
In previous works, we have shown that insulin-like growth factor-binding protein-3 (IGFBP-3), a tissue and circulating protein able to bind to IGFs, decreases drastically in the blood serum of patients with diffuse metastatic melanoma.
Londei, Paola, Martella, M, Naspi, A, Panasiti, Vincenzo, Polinari, Dorina, Rosa Alba, R, Sancillo, L, Zingariello, M   +7 more
core   +1 more source

Insulin-Like Growth Factor I, Insulin-like Growth factor Binding Protein 3, and Atrial Fibrillation in the Elderly [PDF]

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2013
Insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) are involved in oxidative stress and atherosclerosis; however, the relationship between the IGF-I system and atrial fibrillation (AF) is not known. The objective of this analysis was to assess, the relationship between IGF-I and IGFBP-3 serum levels and AF ...
Emmanuelle, Duron, Jean-Sébastien, Vidal, Benoît, Funalot, Nadège, Brunel, Cécile, Viollet, Marie-Laure, Seux, Jean-Marc, Treluyer, Jacques, Epelbaum, Yves Le, Bouc, Olivier, Hanon   +9 more
openaire   +2 more sources

Malnutrition in children associated with low insulin-like growth factor binding protein-3 (IGFBP-3) levels

Gaceta Sanitaria, 2021
Objective: This study aimed to compare serum levels of Insulin-like Growth Factor Binding Protein-3 in children with malnutrition and good nutritional status.
Dwi Ayu Rahmawati, Aminuddin Aminuddin, Firdaus Hamid, Prihantono Prihantono, Burhanuddin Bahar, Veni Hadju   +5 more
doaj   +1 more source

Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action [PDF]

, 2005
We have reported previously that mutation of two conserved nonbasic amino acids (G203 and Q209) within the highly basic 201–218 region in the C-terminal domain of IGF-binding protein-5 (IGFBP-5) decreases binding to IGFs.
Andress, Andress, Arai, Arai, Beattie, Bramani, Carrick, Chernausek, David J. Flint, Elizabeth Tonner, Firth, Galanis, Gordon J. Allan, Headey, Ho, Huhtala, Hwa, Iain F. Gow, Imai, James Beattie, John H. Shand, Kalus, Kirsten Phillips, Malgorzata Szymanowska, Nam, Nam, Parker, Parker, Payet, Phillips, Provencher, Roger A. Clegg, Schneider, Shand, Sharon M. Kelly, Song, Song, Vorwerk, Wang, Whitmore, Yan   +40 more
core   +1 more source

Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease [PDF]

, 2007
Background: Insulin-like growth factor (IGF)-1 has been implicated in the pathogenesis of Alzheimer's disease ( AD). Methods: We compared the level of circulating total and bioavailable IGF-1, by simultaneous measurements of IGF-1 and IGF binding ...
Bowie, P.C.W, Grant, P.J, Holmes, J.D, Hooper, N.M, Rice, P.J, Vardy, E.R.L.C   +5 more
core   +1 more source

Insulin-like growth factor-I and insulin-like growth factor binding protein-3 serum levels in ankylosing spondylitis [PDF]

Rheumatology, 1998
Low bone mass, vertebral osteopenia and fractures have been described in patients with ankylosing spondylitis (AS), but the aetiology of this osteoporosis (OP) remains unknown. Insulin-like growth factor-I (IGF-I), a bone-promoting peptide, may be considered as reflecting osteoblast function as well as its main binding protein, insulin-like growth ...
E, Toussirot, N U, Nguyen, G, Dumoulin, J, Regnard, D, Wendling   +4 more
openaire   +2 more sources

Insulin-like growth factor 1 and insulin-like growth factor binding protein-3 as predictive biomarkers of depression and migraine in obese women

The Egyptian Journal of Internal Medicine, 2019
Introduction Obesity and its comorbidity, depression and migraine, are highly prevalent conditions and public health problems of enormous scope that are responsible for the significant quality of life impairment and financial cost.
Nearmeen M Rashad, Ahmed F Gomaa, Hanan M Sabry, Amira A Fouad, Shereen M El Shabrawy   +4 more
doaj   +1 more source

Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain [PDF]

, 2005
Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are ubiquitously distributed across cell types and vertebrate species. The rules that govern calpain specificity have not yet been determined.
Andress, Baxter, Booth, Croall, Croall, Fielder, Fischer, Fowlkes, Goll, Harris, Kumamoto, Kuwaki, Lalou, Sasaki, Shih, Sorimachi   +15 more
core   +1 more source

Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]

, 2020
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo, Benner, Chris, Brenner, David, Chen, Yibu, Diggle, Karin, Dorko, Ken, Hosseini, Mojgan, Kisseleva, Tatiana, Lam, Kevin, Liu, Xiao, Meshgin, Nairika, Musallam, Sami G, Pan, Stephanie Q, Presnell, Sharon, Rosenthal, Sara Brin, Tsukamoto, Hidekazu, Wu, Raymond   +16 more
core   +1 more source

Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals. [PDF]

, 2015
BackgroundClinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown.MethodsWe ...
Choi, Namjong, Lee, Sunhee C, Letendre, Scott, Lo, Yungtai, Suh, Hyeon-Sook   +4 more
core   +2 more sources