Results 71 to 80 of about 31,548,076 (283)
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
مجله دانشکده پزشکی اصفهان, 2017 Insulin-like growth factor-binding protein 3 (IGFBP-3) is the most abundant IGFBP in circulation, interacts with high affinity to IGFs altering their function. Emerging evidence has indicated that IGFBP3 mostly involved in human disease such as diabetes,
Amir Ansari +2 more
doaj
Endocrinology Research and Practice, 2023 Objective: Energy deprivation induces changes in various components of the “growth hormone”/“insul in-like growth factor-I” axis; however, it remains unclear whether Ramadan fasting could alter which ones in response to food deprivation.
Majid Reza Sheikh Rezaee +4 more
doaj
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Associations of insulin‐like growth factor and insulin‐like growth factor binding protein‐3 with mortality in women with breast cancer [PDF]
International Journal of Cancer, 2012 AbstractElevated circulating insulin‐like growth factor‐1 (IGF‐1), a breast epithelial cell mitogen, is associated with breast cancer development. However, its association with breast cancer survival is not established. Circulating concentrations of IGF‐1 are controlledviabinding proteins, including IGF Binding Protein‐3 (IGFBP‐3), that may modulate ...
Catherine, Duggan +10 more
openaire +2 more sources
Molecular networks in FGF signaling: Flotillin-1 and Cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2 [PDF]
, 2012 Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Traub Stephanie +11 more
core +2 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Endocrine Connections, 2018 The growth hormone (GH)–insulin-like growth factor (IGF)-I axis is a key endocrine mechanism regulating linear growth in children. While paediatricians have a good knowledge of GH secretion and assessment, understanding and use of measurements of the ...
Werner F Blum +6 more
doaj +1 more source
Effects of alcohol on insulin-like growth factor I and insulin-like growth factor binding protein 3 in postmenopausal women [PDF]
The American Journal of Clinical Nutrition, 2005 Increased circulating insulin-like growth factor I (IGF-I) concentrations, frequently adjusted for IGF binding protein 3 (IGFBP-3), have been associated with increased risk of several types of cancer, including colon, prostate, and breast. Studies have suggested that alcohol may affect IGF-I or IGFBP-3; however, controlled feeding studies to assess ...
Jackie A, Lavigne +12 more
openaire +2 more sources
Sex steroids, growth factors and mammographic density: a cross-sectional study of UK postmenopausal Caucasian and Afro-Caribbean women. [PDF]
, 2009 INTRODUCTION: Sex steroids, insulin-like growth factors (IGFs) and prolactin are breast cancer risk factors but whether their effects are mediated through mammographic density, one of the strongest risk factors for breast cancer, is unknown.
Isabel dos Santos Silva +29 more
core +2 more sources