Results 261 to 270 of about 1,058,875 (320)

A cost-utility analysis of long-acting insulin analogues (detemir, glargine and degludec) for the treatment of adult type 1 diabetes in South Africa. [PDF]

Cost Eff Resour Alloc
Verryn MT, Cleary S.
europepmc   +1 more source

Biological Reinforced Concrete for Cartilage Repair With 3D Printing

Advanced Science, EarlyView.
Inspired by concrete rebar structures in engineering, the concept of biological reinforced concrete uses 3D‐printed ultrafine fiber networks (UFNs) as biodegradable “biorebars”， hybrid biohydrogels as “biocement”， and stem cells as “bioactive aggregates” to fabricate biomimetic cartilage.
Yuewei Chen, Tao Fu, Zhongfei Zou, Yanming Liu, Jianguo Zhu, Binhong Teng, Ke Yao, Haibin Li, Jiachun Li, Zhijian Xie, Yong He   +10 more
wiley   +1 more source

Effect of Roux-en-Y gastric bypass on patients with type 2 diabetes mellitus and body mass index of 27.5-35 kg/m²-a single center retrospective cohort study. [PDF]

BMC Surg
Gao X, Wang T, Li J, Li W, Zhu L, Zhu S, Song Z, Li P.   +7 more
europepmc   +1 more source

Chromosome‐Level Genome Assembly of the Leafcutter Bee Megachile rotundata Reveals Its Ecological Adaptation and Pollination Biology

Advanced Science, EarlyView.
The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi, Pan Duan, Mengmeng Zhu, Rong Zhang, Zihua Zhao, Xin Nie, Hanhou He, Li Hou, Xianhui Wang   +8 more
wiley   +1 more source

FFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes. [PDF]

Nat Commun
Chen X, Shao J, Brandenburger I, Qian W, Hahnefeld L, Bonnavion R, Cho H, Wang S, Hidalgo J, Wettschureck N, Geisslinger G, Gurke R, Wang Z, Offermanns S.   +13 more
europepmc   +1 more source

Enhancing Tendon Regeneration: Investigating the Impact of Topography on the Secretome of Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The impact of topography on the secretome of adipose‐derived stem cells (ADSCs) has the potential for promoting tendon regeneration. The secretome generated from ADSCs on aligned structure has a potent effect in promoting cell migration, proliferation, tenogenic differentiation, macrophage M2 polarization, and tendon mechanical function recovery ...
Qiuzi Long, Chuanquan Liu, Haotian Zheng, Mingyue Wang, Hanmei Liu, Yue Liu, Zhicheng Cao, Yuzhi Sun, Qingyun Mo, Ludvig J. Backman, Jialin Zhu, Lizhi Hu, Jinlong Huang, Wei Zhang, Jialin Chen   +14 more
wiley   +1 more source

Functional profiling of synthetic camel milk-derived peptides with implication in glucose transport and diabetes. [PDF]

PLoS One
Anwar I, Khan FB, Baby B, Antony P, Mudgil P, Gan CY, Maqsood S, Vijayan R, Muhammad K, Ayoub MA.   +9 more
europepmc   +1 more source

DiffMC‐Gen: A Dual Denoising Diffusion Model for Multi‐Conditional Molecular Generation

Advanced Science, EarlyView.
DiffMC‐Gen, a dual‐diffusion model for 2D and 3D molecular generation, simultaneously optimizes multiple key objectives across the drug design process, enabling the generation of novel, target‐specific small‐molecule ligands with high therapeutic potential.
Yuwei Yang, Shukai Gu, Bo Liu, Xiaoqing Gong, Ruiqiang Lu, Jiayue Qiu, Xiaojun Yao, Huanxiang Liu   +7 more
wiley   +1 more source

Addressing the Diabetes Tsunami Requires Expanded Access to Diabetes Technologies. [PDF]

J Diabetes Sci Technol
Kruger DF, Parkin CG, Hirsch IB, Aleppo G, McGill JB, Galindo RJ, Levy CJ, Umpierrez GE, Grunberger G, Bergenstal RM.   +9 more
europepmc   +1 more source