Results 311 to 320 of about 2,674,610 (386)

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

CD36 attenuates pressure overload-induced myocardial insulin resistance via HSF1-dependent HSP90α suppression and competitive disruption of the HSP90α-InsR complex. [PDF]

J Transl Med
Shu H, Li N, Zhao Q, Zhang Z, Qin Y, Nie J, Wang DW, Zhou N.   +7 more
europepmc   +1 more source

Emerging Nanotechnology Strategies for Obesity Therapy

Advanced Science, EarlyView.
Three types of nanomaterials used for obesity treatment are highlighted, including inorganic nanomaterials, organic nanomaterials and biomimetic nanomaterials. A detailed and comprehensive introduction to the recent nanotechnology strategies for obesity management is also provided, including drug delivery, photodynamic therapy, hyperthermia, gas ...
Weili Chang, Zhaoxu Meng, Yuezhu Zhao, Yake Qi, Zhou Li, He Lian   +5 more
wiley   +1 more source

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

Advanced Science, EarlyView.
This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen, YuWei Zhou, LongXiang Sheng, FangYing Mai, YuXuan Ding, ShiRan Hong, JiaXin Wu, JiaKai Pi, GuangMei Yan, YiJun Huang, JingJing Duan, Xuefeng Hua, Wei Yin   +12 more
wiley   +1 more source

Kefir-derived exopolysaccharide ameliorates hyperglycemic control and beta cell integrity in a rat model of type 2 diabetes mellitus. [PDF]

Nutr Diabetes
Yen CC, Tsai CL, Chang GR, Ko CH, Tu MY, Lan YW, Chen HL, Chen CM.   +7 more
europepmc   +1 more source

An unexpected role for the brain in the pathogenesis of diabetic ketoacidosis. [PDF]

J Clin Invest
Mirzadeh Z, Morton GJ, Hirsch IB, Schwartz MW.   +3 more
europepmc   +1 more source

Understanding Insulin Actions Beyond Glycemic Control: A Narrative Review. [PDF]

J Clin Med
Riachi R, Khalife E, Kędzia A, Niechciał E.   +3 more
europepmc   +1 more source

High intensity interval training attenuate insulin resistance in diabetic rats accompanied by improvements in liver metabolism and spexin signaling. [PDF]

Sci Rep
Khoramipour K, Hosseini NS, Hill JW, Khoramipour K, Khoramipour K, Izquierdo SM, Lista S, Saheli M.   +7 more
europepmc   +1 more source