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Insulins for Insulin Resistance
Annals of Internal Medicine, 1981Excerpt To the editor: Dr. Galloway (1) notes in his comment on our article "U-500 Insulin in the Treatment of Antibody-Mediated Insulin Resistance" (2) that we did not compare equivalent doses of ...
David M. Nathan, Lloyd Axelrod
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Insulin autoantibodies and insulin assay
Diabetes, 1988Insulin antibodies are known to interfere with the radioimmunoassay of insulin. We tested intravenous glucose tolerance on 25 insulin autoantibody-positive (IAA+) patients and 25 IAA− controls, who were matched for sex, age, and body mass index, to establish if IAA could also interfere with insulin assay. Insulin content was measured in untreated serum,
Peter J. Wood +4 more
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Insulin, insulin receptors, and cancer
Journal of Endocrinological Investigation, 2016Insulin is a major regulator of cell metabolism but, in addition, is also a growth factor. Insulin effects in target cells are mediated by the insulin receptor (IR), a transmembrane protein with enzymatic (tyrosine kinase) activity. The insulin receptor, however, is represented by a heterogeneous family of proteins, including two different IR isoforms ...
Vigneri R +2 more
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Insulin Resistance and Insulin Sensitizers
Hormone Research in Paediatrics, 2001Insulin resistance is a key factor in the pathogenesis of type 2 diabetes mellitus and a co-factor in the development of dyslipidaemia, hypertension and atherosclerosis. The causes of insulin resistance include factors such as obesity and physical inactivity, and there may also be genetic factors.
Michael Stumvoll, Hans U. Häring
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Insulin in blood and insulin antibodies
The American Journal of Medicine, 1966T HIS presentation is concerned with the state of insulin in plasma rather than the physiologic regulation of insulin secretion. Our own studies on the concentrations of immunoassayable insulin in blood in hyperglycemic and hypoglycemic states have recently been summarized elsewhere [ 7-31.
Rosalyn S. Yalow, Solomon A. Berson
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SERUM-INSULIN OR PLASMA-INSULIN ?
The Lancet, 1970Abstract The concentration of insulin was measured by double-antibody immunoassay simultaneously in the plasma and serum of thirty-eight fasting and non-fasting individuals. The concentration found in heparin-plasma was consistently higher than that found in serum, and experiments suggest that the high plasma-level is an effect of heparin.
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Insulin Antibodies and Insulin Autoantibodies
Diabetic Medicine, 1991Antibodies to insulin are of two types, insulin antibodies which occur in patients who have been exposed to exogenous insulin treatment, and insulin autoantibodies which appear in insulin-naive subjects. The occurrence and clinical significance of the two types of antibody hardly overlap, and they will be discussed ...
C. J. Greenbaum, Jerry P. Palmer
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Insulin, insulin sensitivity and hypertension
Journal of Hypertension, 1990The sensitivity of tissue to insulin is of physiological, pathophysiological and therapeutic relevance. The quantity of insulin and the response to insulin are paramount complementary factors in the regulation of glucose metabolism, and may, at least under certain pathophysiological conditions, also affect cardiovascular function.
Paolo Ferrari, Peter Weidmann
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Insulin resistance: Review of the underlying molecular mechanisms
Journal of Cellular Physiology, 2018Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues.
Habib Yaribeygi +3 more
semanticscholar +1 more source