Automated Insulin Delivery for Type 1 Diabetes Mellitus Patients using Gaussian Process-based Model Predictive Control [PDF]
American Control Conference (ACC) 2019, 2021 The human insulin-glucose metabolism is a time-varying process, which is partly caused by the changing insulin sensitivity of the body. This insulin sensitivity follows a circadian rhythm and its effects should be anticipated by any automated insulin delivery system. This paper presents an extension of our previous work on automated insulin delivery by
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Glargine Insulin Is Not an Alternative in Insulin Allergy [PDF]
Diabetes Care, 2003 Allergy to insulin is rare with human recombinant insulin and is now reported for
Nicolas Guillausseau +3 more
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Insulin glargine affects the expression of Igf-1r, Insr, and Igf-1 genes in colon and liver of diabetic rats [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): The mitogenic effect of the analogous insulin glargine is currently under debate since several clinical studies have raised the possibility that insulin glargine treatment has a carcinogenic potential in different tissues.
Clara I Juárez-Vázquez +8 more
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Insulin glargine: a new basal insulin analogue [PDF]
QJM, 2002 Currently, the therapeutic challenges in the treatment of both type 1 and 2 diabetes mellitus (DM) are the maintenance of near‐normal glycaemia, to prevent long‐term complications,1,,2 and the avoidance of episodes of hypoglycaemia. For many people with DM, intensive insulin therapy means multiple insulin injections and frequent blood sampling, at the ...
N. Younis, D. Bowen‐Jones, H. Soran
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Cancer risk associated with insulin glargine among adult type 2 diabetes patients--a nationwide cohort study. [PDF]
PLoS ONE, 2011 BACKGROUND: Preclinical and observational studies raise the concern about the safety of insulin glargine in terms of cancer initiation and promotion.
Chia-Hsuin Chang +6 more
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Insulin Edema Associated With Glargine
JCEM Case Reports, 2023 Abstract Insulin edema is a poorly understood complication of insulin therapy. It has been reported in patients with both type 1 and 2 diabetes mellitus and typically occurs in patients with newly diagnosed or poorly controlled diabetes mellitus either after initiation or intensification of insulin therapy.
Jessica Wood +3 more
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Temporal patterns in insulin needs for Type 1 diabetes [PDF]
JMIRx Med 5(1):e44384 (2024), 2022 Type 1 Diabetes (T1D) is a chronic condition where the body produces little or no insulin, a hormone required for the cells to use blood glucose (BG) for energy and to regulate BG levels in the body. Finding the right insulin dose and time remains a complex, challenging and as yet unsolved control task.
arxiv +1 more source
Insulin glargine: pharmacokinetic and pharmacodynamic basis of clinical effect
Сахарный диабет, 2014 Glargine became the first long-acting insulin analogue. Glargine was designed to meet basal insulin requirements throughout the day with a single injection.
Vadim Valer'evich Klimontov +1 more
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Increasing the production of insulin glargine in Pichia pastoris through medium modification [PDF]
BIO Web of ConferencesInsulin is the primary drug for managing diabetes mellitus, especially for individuals with type 1 diabetes mellitus. Producing insulin glargine, a long-acting insulin analogue, using Pichia pastoris is a notable advancement in biopharmaceutical ...
Hardianto Dudi +7 more
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Safety of Insulin Glargine in Pregnancy [PDF]
Journal of Diabetes & Metabolism, 2013 Aim: Although insulin glargine is frequently being used in pregnancy, it is not approved by the FDA as the data on its safety is limited. The aim of this study was to determine the effects of insulin glargine use in pregnancy on maternal and fetal outcomes.
Ved V. Gossain +5 more
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