Results 51 to 60 of about 533,242 (221)

Comparison of Insulin Hypersensitivity of Adrenalectomized and of Hypophysectomized Dogs.

Experimental Biology and Medicine, 1952
Summary and ConclusionsThe adrenaleo-tomized dog is more sensitive to insulin than the normal dog but less sensitive than the hypophysectomized dog. This is true so long as the adrenalectomized dog, whether with or without DCA maintenance, is still well-nourished and tested only in the post-absorptive state.
R C, DE BODO, M W, SINKOFF, S P, KIANG
openaire   +2 more sources

Pharmacokinetics and safety of a modified‐release psilocybin formulation: A SAD Phase I trial in normal‐weight and overweight/obese participants

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the safety, tolerability and pharmacokinetics of a novel oral modified‐release psilocybin formulation (REL‐P11) in normal‐weight and overweight/obese healthy adults and to assess its suitability for controlled, subperceptual exposure, in light of emerging evidence supporting serotonergic modulation in metabolic ...
Anna Signor, Stefano Comai, Gianfranco Pasut, Franco Folli, Marco Gentilucci, Negar Gharavi, Sofia Raitsin, Thuy Van Nguyen, Marco Pappagallo, Andrea Mattarei, Paolo L. Manfredi, Sara De Martin   +11 more
wiley   +1 more source

Successful Management of Insulin Allergy and Autoimmune Polyendocrine Syndrome Type 4 with Desensitization Therapy and Glucocorticoid Treatment: A Case Report and Review of the Literature

Case Reports in Immunology, 2014
Introduction. Insulin allergy is a rare complication of insulin therapy, especially in type 1 diabetes mellitus (T1DM). Key manifestations are hypersensitivity-related symptoms and poor metabolic control.
Joselyn Rojas, Marjorie Villalobos, María Sofía Martínez, Mervin Chávez-Castillo, Wheeler Torres, José Carlos Mejías, Edgar Miquilena, Valmore Bermúdez   +7 more
doaj   +1 more source

Enhancing Evidence Generation by Linking Randomized Clinical Trials to Real‐World Data: The INVESTED‐Medicare Linkage Study

Clinical Pharmacology &Therapeutics, EarlyView.
Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho, HoJin Shin, Mehdi Najafzadeh, Brian Claggett, Janinne Ortega‐Montiel, Jun Liu, Julie M. Paik, Narlina F. Lalani, Marie C. Bradley, John Concato, Scott D. Solomon, Orly Vardeny, Elisabetta Patorno   +12 more
wiley   +1 more source

Composition of allogeneic equine orthobiologics and their repeated intra‐articular administrations

Equine Veterinary Journal, EarlyView.
Abstract Background Orthobiologics such as platelet‐rich plasma (PRP) and alpha‐2‐macroglobulin (A2MG) are increasingly used for equine musculoskeletal injuries. However, their composition and safety with repeated allogeneic intra‐articular administration remain poorly investigated.
Yanne Van Reusel, Sarah Y. Broeckx, Anna Carolo, Marco Patruno, Jonas Steenbrugge, Jimmy Saunders, Enrico Gugliandolo, Jan H. Spaas   +7 more
wiley   +1 more source

Inzulin-túlérzékenységi reakció vagy valami más? Tanulságok egy eset kapcsán = Lessons from a case of suspected insulin allergy [PDF]

, 2020
Today, insulin hypersensitivity reactions are rare side effects of insulin therapy. In two-thirds of the suspected insulin allergy cases, the clinical symptoms are not related to insulin.
Péter Gergely, Adrienn Halász, Márton, Dalma Fanni, Halasz, Adrienn, Nagy, Eszter, Dalma Fanni Márton, Anikó Somogyi, Komlósi, Zsolt, Eszter Nagy, Somogyi, Anikó, Zsolt István Komlósi, Gergely, Péter   +11 more
core   +1 more source

Investigating the Role of Insulin-Like Signaling in Paclitaxel-Induced Nociceptive Hypersensitivity using Drosophila melanogaster [PDF]

Paclitaxel (PTX), a chemotherapeutic that alters microtubule dynamics, is known to induce nociceptive hypersensitivity and sensory neuron damage in human patients and in Drosophila larvae.
Sridharan, Sreepradha
core   +1 more source

Comprehensive Review on Advancements in Food Preservation Technologies for Quality and Sustainability

Food Chemistry International, EarlyView.
Preservatives limit microbial development, oxidation, and enzymatic degradation, resulting in better food quality and extended shelf life. Classified as natural, synthetic, or biological, each preservative has distinctive attributes and modes of action. Growing preference for natural preservatives aligns with clean label trends.
Monica Suresh, Arun Meyyazhagan, Haripriya Kuchi Bhotla, Manikantan Pappuswamy, Balamuralikrishnan Balasubramanian   +4 more
wiley   +1 more source

The modification of insulin to enhance oral delivery systems [PDF]

, 2009
textWhile a number of PEGylated proteins have been studied for injectable applications and reviewers have used this data to speculate possible oral delivery improvements, a detailed investigation of PEGylated insulin for oral delivery and the development
Kanzelberger, Melissa Ann
core  

Hypothalamic glucose hypersensitivity induced insulin secretion in the obese Zücker rat is reversed by central ghrelin treatment

, 2023
Published ahead of print: 7 March 2023International audienceAIMS: Part of hypothalamic (MBH) neurons detect changes in blood glucose level that coordinate in return the vagal control of insulin secretion.
Liénard, Fabienne, Allard, Camille, Haydar, Joulia, Jacquin-Piques, Agnès, Fioramonti, Xavier, Pénicaud, Luc, Brindisi, Marie-Claude, Paccoud, Romain, Abed, Besma, Leloup, Corinne, Desmoulins, Lucie, Mouillot, Thomas, Grall, Sylvie, Brondel, Laurent, Fenech, Claire, Carneiro, Lionel, Luc Pénicaud, Lionel Carneiro, Camille Allard, Lucie Desmoulins, Romain Paccoud, Thomas Mouillot, Joulia Haydar, Corinne Leloup, Sylvie Grall, Claire Fenech, Xavier Fioramonti, Agnès Jacquin-Piques, Fabienne Liénard, Besma Abed, Laurent Brondel, Marie-Claude Brindisi   +31 more
core   +1 more source