Results 91 to 100 of about 4,925,583 (301)

Role of Myotonic Dystrophy Protein Kinase [DMPK] in Glucose Homeostasis and Muscle Insulin Action [PDF]

, 2007
Myotonic dystrophy 1 (DM1) is caused by a CTG expansion in the 3′-unstranslated region of the DMPK gene, which encodes a serine/threonine protein kinase. One of the common clinical features of DM1 patients is insulin resistance, which has been associated
Liesa Marc, Ciaraldi, Theodore P, Martí, Luc, Ciaraldi, Theodore P., Palacin, Manuel, Catalucci, Daniele, Wolfgang H Dillmann, Esther Llagostera, Perla Kaliman, Catalucci Daniele, Camps, Marta, Reddy, Sita, Gomis, Ramon, 1946-, Luc Marti, Llagostera Martín, Esther, Antonio Zorzano, Ciaraldi Theodore P., Dillmann, Wolfgang H, Llagostera Esther, Gomis Ramon, Reddy Sita, Camps Marta, Dillmann, Wolfgang H., Kaliman Perla, Sita Reddy, Kaliman, Perla, Ruiz-Lozano Pilar, Llagostera, Esther, Richard Kondo, Ruiz-Lozano, Pilar, Zorzano Olarte, Antonio, Manuel Palacin, Zorzano Antonio, Kondo, Richard, Palacín Prieto, Manuel, Ramon Gomis, Daniele Catalucci, Liesa Torre-Marín, Montserrat, Dillmann Wolfgang H., Marti Luc, Camps Camprubí, Marta, Zorzano, Antonio, Marta Camps, Pilar Ruiz-Lozano, Liesa, Marc, Kondo Richard, Gomis, Ramon, Marc Liesa, Theodore P Ciaraldi, Palacin Manuel   +49 more
core   +2 more sources

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Assessment of methods and indexes of insulin sensitivity

Endocrinology Insights, 2014
AbstractInsulin resistance contributes to the pathophysiology of diabetes and is a hallmark of obesity, metabolic syndrome, and many cardiovascular diseases. Therefore, quantifying insulin sensitivity/resistance in humans and animal models is of great importance.Various methods are used to assess insulin sensitivity both in individuals and in study ...
Patarrão, Rita S., Wayne Lautt, Wilford, Paula Macedo, Maria   +2 more
openaire   +1 more source

Lipid Subclasses Differentiate Insulin Resistance by Triglyceride–Glucose Index

Metabolites
Background: Insulin resistance is a key driver of metabolic syndrome and related disorders, yet its underlying metabolic alterations remain incompletely understood.
Khaled Naja, Najeha Anwardeen, Omar Albagha, Mohamed A. Elrayess   +3 more
doaj   +1 more source

Association between plasma leptin/adiponectin ratio and insulin resistance indexes in prepubertal children [PDF]

Archives of Endocrinology and Metabolism
Objective: To assess the association between leptin/adiponectin ratio (LAR) and insulin resistance surrogates in prepubertal children. Subjects and methods: Study based on data from the Growth and Obesity Chilean Cohort Study (GOCS) involving 968 ...
Carolina Bravo, Verónica Mericq, Ana Pereira, Camila Corvalán, Hugo E. Tobar, José Patricio Miranda, José Luis Santos   +6 more
doaj   +1 more source

Effect of the dietary fat quality on insulin sensitivity. [PDF]

, 2008
Recent evidence shows that specific fatty acids affect cell metabolism, modifying the balance between fatty acid oxidation and lipogenesis. These effects may have important implications in addressing the present epidemic of nutrition-related chronic ...
Aguirre, Carolina A, Uauy Dagach-Imbarack, Ricardo, Galgani Fuentes, José, Díaz Bustos, Erik, Aguirre, Carolina A., Galgani, José E, Uauy, Ricardo D, Díaz, Erik O   +7 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

In vivo Metabolic Imaging of Insulin with Multiphoton Fluorescence of Human Insulin-Au Nanodots

, 2014
Functional human insulin-Au nanodots (NDs) are synthesized for the in vivo imaging of insulin metabolism. Benefiting from its efficient red to near infrared fluorescence, deep tissue subcellular uptake of insulin-Au NDs can be clearly resolved through a ...
王宗道 ;許榮彬 ;林昭維, Liu, Chien-Liang;Liu, Tzu-Ming;Hsieh, Tsung-Yuan;Liu, Han-Wen;Chen, Yu-Shing;Tsai, Cheng-Kun;Chen, Hsieh-Chih;Lin, Jong-Wei;Hsu, Ron-Bin;Wang, Tzung-Dau;Chen, Chien-Cheng;Sun, Chi-Kuang;Chou, Pi-Tai   +1 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Neck and Wrist Circumferences Propose a Reliable Approach to Qualify Obesity and Insulin Resistance

Medicine Science, 2014
Objective of this study is to evaluate the association of neck circumference and wrist circumference with traditional abdominal and general obesity measurement parameters, insulin resistance, insulin resistance-related factors such as blood lipids ...
Banu Taskiran Tatar, Canan Ersoy, Turgut Kacan, Emine Kirhan, Emre Sarandol, Deniz Sigirli, Selen Kacan, Celaleddin Demircan, Sazi Imamoglu   +8 more
doaj   +1 more source