Results 241 to 250 of about 90,099 (312)

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Interference of Intravenous Acetaminophen with Continuous Glucose Monitoring System. [PDF]

JMA J
Matsuyama M, Meiri S, Sawada H, Masuya R, Nakame K, Moritake H.   +5 more
europepmc   +1 more source

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

Continuous vs. intermittent infusion of corticosteroids in septic shock: a GRADE-based systematic review and meta-analysis. [PDF]

J Anesth Analg Crit Care
Mahmoudi PS, Sadeghi F, Saberian M, Khalili H, Shafaati M.   +4 more
europepmc   +1 more source

Injectable Chondroitin Sulfate Methacrylate Hydrogel Microspheres Co‐Loaded with GLPM Nanozyme, Dexamethasone, and Stem Cells for Synergistic Osteoarthritis Therapy

Advanced Science, EarlyView.
A multifunctional injectable microsphere system is fabricated via UV‐assisted microfluidic cross‐linking, integrating nanozyme‐based ROS scavenging, sustained dexamethasone release, and stem cell delivery. Upon IA injection, the microspheres adapt to joint stress, suppress inflammation, and promote cartilage regeneration, offering a minimally invasive ...
Xiaochen Feng, Ying Fang, Hongwei Yu, Yicheng Wang, Yunze Xu, Chunxiao Shi, Haike Xia, Ranjith Kumar Kankala, Aizheng Chen, Shibin Wang, Chaoping Fu   +10 more
wiley   +1 more source

A digital twin-enhanced decision support system improves time-in-range in type 1 diabetes: a randomized clinical trial. [PDF]

Sci Rep
Builes-Montaño CE, Lema-Perez L, Ramírez-Rincón A, Zuleta-Tobón JJ, Restrepo-Gutiérrez JC, Álvarez-Zapata HD, García-Tirado J.   +6 more
europepmc   +1 more source

Evaluation of the insulin-dependent and -independent hypoglycemic effects and understanding their breakdown in the progression of obesity using mice. [PDF]

PLoS One
Kojima F, Morishita S, Uda S, Yutsudo N, Ogawa Y, Kubota H.   +5 more
europepmc   +1 more source

Short- and long-term complications of insulin pump therapy in children and adolescents with type 1 diabetes: a multicenter cross-sectional study from Saudi Arabia. [PDF]

Ther Adv Chronic Dis
Bakkar A, Althobaiti E, Alqahtani I, Abualkhair LA, Kamal NM, Althobaiti M, Alotaibi T, Habib L, Alharthi L, Aljuaid S, Althuwaybi M, Alshehri H, Alotaibi M, Kamal W, Aljuaid M, Almalki S, Alsaedi A.   +16 more
europepmc   +1 more source

DIABASE: an automatically filled single-centre registry of diabetes mellitus in the Netherlands, combining clinical data with real-world longitudinal wearable device data-a study protocol. [PDF]

BMJ Open
Urgert T, Kappert KDR, Veldhuis A, Geerdink J, van Beijnum BJF, Laverman GD.   +5 more
europepmc   +1 more source