Case of subcutaneous insulin resistance syndrome treated with ultra‐rapid insulin lispro [PDF]
Journal of Diabetes Investigation, 2022 Subcutaneous insulin resistance syndrome is a rare condition that causes difficulty in glycemic control due to severe resistance to subcutaneous insulin injections.
Takahiro Ishii +9 more
doaj +2 more sources
Ultra‐Rapid Lispro results in accelerated insulin lispro absorption and faster early insulin action in comparison with Humalog® in Japanese patients with type 1 diabetes [PDF]
Journal of Diabetes Investigation, 2020 Aims/Introduction Ultra‐rapid lispro (URLi) is a novel ultra‐rapid mealtime insulin. This study compared the pharmacokinetic and glucodynamic profiles, safety, and tolerability of URLi and lispro (Humalog®) in Japanese patients with type 1 diabetes ...
Masanari Shiramoto +4 more
doaj +2 more sources
Protocol to Assess the Biological Activity of Insulin Glargine, Insulin Lispro, and Insulin Aspart In Vitro [PDF]
Methods and Protocols, 2023 Insulin is a hormone produced by β-cells of the pancreas and controls the amount of sugar in the blood. Since its discovery over 100 years ago, insulin has been used as a life-saving treatment for people with diabetes.
Mamatha Garige +4 more
doaj +2 more sources
Pharmacokinetics and pharmacodynamics of insulin lispro 25 versus the original preparation (Humalog®25) in Chinese healthy male volunteers [PDF]
Frontiers in PharmacologyBackground: There are approximately 537 million adults with diabetes worldwide, and insulin still plays an important role in its treatment. However, the long-term use of insulin imposes a significant financial burden on patients.
Mingxue Zhu +5 more
doaj +2 more sources
Efficacy and Safety of Intramuscular Insulin Lispro vs. Continuous Intravenous Regular Insulin for the Treatment of Dogs With Diabetic Ketoacidosis [PDF]
Frontiers in Veterinary Science, 2020 The use of rapid-acting insulin analogs as routes of administration other than IV has never been described for the treatment of dogs with diabetic ketoacidosis (DKA).
Eleonora Malerba +4 more
doaj +2 more sources
Nano-Amounts of Glucagon Premixed With Fast-Acting Insulin Lispro: Effect on Insulin Absorption in Pigs [PDF]
Current Therapeutic ResearchBackground: Glucagon leads to substantial but short-lived subcutaneous vasodilation. Using micro-amounts of glucagon at the insulin injection site increases insulin absorption.
Ilze Dirnena-Fusini, PhD +3 more
doaj +2 more sources
The Silver Jubilee (2025) of Insulin Glargine: Introducing the Era of Long‐Acting Insulin Analogues for Diabetes Mellitus [PDF]
Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5527-5541, July 2026.ABSTRACT In the year 2000 the first once daily long‐acting bioengineered insulin analogue (LAIA), insulin glargine (‘glargine’), a true basal insulin (BI), became available for clinical use. This led to the decline in the 50‐year‐old era and prominence of the intermediate‐acting insulins, neutral protamine Hagedorn (NPH) and lente, requiring twice ...
Geremia B. Bolli +9 more
wiley +2 more sources
Molecular Metabolism, 2022 Objective: Ultra-rapid insulin formulations control postprandial hyperglycemia; however, inadequate understanding of injection site absorption mechanisms is limiting further advancement.
Anjul Khadria +15 more
doaj +1 more source
Cardiovascular Diabetology, 2023 Objective Basal insulin glargine has a neutral effect on cardiovascular risk in type 2 diabetes (T2DM). In practice, basal insulin is often paired with a glucagon-like peptide-1 receptor agonist (GLP1-RA) or meal insulin; however, the cardiovascular ...
Ravi Retnakaran +5 more
doaj +1 more source
Two Cases of Allergy to Insulin in Gestational Diabetes [PDF]
Endocrinology and Metabolism, 2015 Allergic reaction to insulin is uncommon since the introduction of human recombinant insulin preparations and is more rare in pregnant than non-pregnant females due to altered immune reaction during pregnancy.
Gi Jun Kim +10 more
doaj +1 more source