Results 51 to 60 of about 412,643 (184)

Evaluating the Performance of Traditional Pharmacoepidemiologic and Machine Learning Models to Predict Pregnancies at Risk of Major Congenital Malformations

open access: yesBirth Defects Research, Volume 118, Issue 9, September 2026.
ABSTRACT Background With approximately 50% of pregnancies being unplanned, there is an unintended exposure to potential feto‐toxic drugs that may cause major congenital malformations (MCM). This study aims to compare the predictive performance between traditional pharmacoepidemiologic (PE) and machine learning (ML) models. Methods We conducted a cohort
Gabra Nohmie   +7 more
wiley   +1 more source

Pharmacokinetics of insulin lispro in type 2 diabetes during closed-loop insulin delivery

open access: yes, 2014
Insulin pharmacokinetics is not well understood during continuous subcutaneous insulin infusion in type 2 diabetes (T2D). We analyzed data collected in 11 subjects with T2D [6 male, 9 white European and two of Indian ethnicity; age 59.7(12.1) years, BMI ...
Hovorka, Roman   +3 more
core   +1 more source

Prevalence of Vitamin D Deficiency and Its Association With PTH and Type 1 Diabetes Mellitus (T1DM) in a Multicultural Pediatric Population in the United Arab Emirates, 2023

open access: yesJournal of Diabetes, Volume 18, Issue 9, September 2026.
This cross‐sectional study conducted in the United Arab Emirates investigated Vitamin D status in 102 pediatric patients (ages 3–18) with Type 1 Diabetes Mellitus in the United Arab Emirates, revealing a high prevalence of Vitamin D insufficiency that frequently presents alongside normal parathyroid hormone levels.
Mariam K. Ibrahim   +4 more
wiley   +1 more source

The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy [PDF]

open access: yes, 2014
The discovery of increased formation of methylglyoxal (MG) by cell metabolism in high glucose concentration in vitro suggested possible relevance to diabetes and diabetes complications (1,2).
Rabbani, Naila, Thornalley, Paul J.
core   +1 more source

How the First 9 Months Shape the Rest of Your Life: The Impact of Gestational Diabetes on the Metabolic Future

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 7705-7718, September 2026.
ABSTRACT Gestational diabetes mellitus (GDM) represents far more than a transient glycaemic disorder: it is a sentinel metabolic event that unveils pre‐existing defects in β‐cell function and insulin action, with profound implications for both maternal and offspring cardiometabolic health across the lifespan.
Mustafa Kanat   +2 more
wiley   +1 more source

Aspart and lispro insulin, is there any difference when used with an insulin pump treatment?

open access: yes, 2006
The DCC and the EDIC study studies showed the significance of intensive insulin treatment in reducing blood glucose levels and delaying the onset/progression of cardiovascular disease and microvascular complications. To minimise cardiovascular risk it is
Scaramuzza A.   +7 more
core   +1 more source

A randomized controlled trial-based algorithm for insulin-pump therapy in hyperglycemic patients early after kidney transplantation.

open access: yesPLoS ONE, 2018
Treating hyperglycemia in previously non-diabetic individuals with exogenous insulin immediately after kidney transplantation reduced the odds of developing Posttransplantation Diabetes Mellitus (PTDM) in our previous proof-of-concept clinical trial.
Johannes M Werzowa   +14 more
doaj   +1 more source

One Week Exposure to a Somatostatin Receptor 2 Antagonist (SSTR2a) Enhances Glucagon Counterregulation to Insulin‐Induced Hypoglycaemia and Does Not Worsen Glycemia in a Male Rat Model of Insulin‐Requiring Type 2 Diabetes

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8208-8218, September 2026.
ABSTRACT Introduction Administration of a somatostatin receptor 2 antagonist (SSTR2a) increases glucagon responsiveness to hypoglycaemia in insulin‐treated type 2 diabetes (T2D), but the durability of this effect and the impact of repeated SSTR2a dosing on overall glycaemia in T2D are unclear.
Ninoschka C. D'Souza   +7 more
wiley   +1 more source

Initiation and intensification of insulin therapy in patients with type 2 diabetes mellitus: a budget impact analysis

open access: yesФармакоэкономика, 2017
To date, several options for starting and intensifying insulin therapy in patients with type 2 diabetes mellitus (T2DM) have been proposed. Meta-analyzes of the recent results shows that, with adequate use, all these regimens have the similar efficacy ...
E. V. Biryukova, V. I. Ignat’eva
doaj   +1 more source

Impact of system updates for sensor‐augmented pump therapy on glycemic management in Japanese individuals with type 1 diabetes (SAP‐J T1D study)

open access: yesJournal of Diabetes Investigation, Volume 17, Issue 9, Page 1499-1505, September 2026.
Sequential updates from MiniMed 620G to 640G and then to 770G were associated with stepwise improvements in glycemic management in Japanese individuals with type 1 diabetes. The transition to MiniMed 640G was mainly associated with reduced hypoglycemia, whereas the subsequent transition to MiniMed 770G was associated with reduced hyperglycemia.
Shuichiro Saito   +9 more
wiley   +1 more source

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