Results 81 to 90 of about 66,079 (291)
CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation
Advanced Science, EarlyView.ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu +10 more
wiley +1 more source
Metabolic decompensation in pump users due to lispro insulin precipitation [PDF]
, 2002 Howard Wolpert +3 more
openalex +1 more source
Advanced Science, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang +9 more
wiley +1 more source
International journal of clinical practice. Supplement, 2010 Insulin pump therapy is now more than 30 years old, and is an established part of the routine care of selected people with type 1 diabetes. Nevertheless, there are still significant areas of concern, particularly how pumps compare with modern injection therapy, whether the increasingly sophisticated pump technologies like onboard calculators and ...
openaire +3 more sources
Pump insulin therapy in pediatric practice
Лечащий Врач, 2021 This article presents the results of use of pump insulin therapy in type 1 diabetes mellitus in children. The collected data characterize the method of pump insulin therapy as an excellent instrument for achieving glycemic targets and improving the ...
O. V. Stotikova +2 more
doaj
BENEFITS OF INSULIN ASPART VS PHOSPHATE-BUFFERED HUMAN REGULAR INSULIN IN PERSONS WITH TYPE 1 DIABETES TREATED BY MEANS OF AN INSULIN PUMP [PDF]
, 2004 Rudolf Chlup +5 more
openalex +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
Modeling and Simulation of Insulin Pump Set Failures Based on the Power Flow Method
IEEE AccessThe insulin pump is a critical device for intensive insulin therapy in diabetic patients. Failures in insulin pump sets such as blockage and leakage can disrupt normal insulin delivery, potentially causing hyperglycemia or life-threatening diabetic ...
Weijie Wang +3 more
doaj +1 more source
Safety of Insulin Lispro and a Biosimilar Insulin Lispro When Administered Through an Insulin Pump [PDF]
, 2018 James Thrasher +6 more
openalex +1 more source