IMMUNOLOGIC STUDIES IN INSULIN RESISTANCE. III. MEASUREMENT OF AN INSULIN ANTAGONIST IN THE SERUM OF AN INSULIN-RESISTANT PATIENT BY THE BLOOD SUGAR CURVE METHOD IN MICE [PDF]
, 1947 Francis C. Lowell
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Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2 [PDF]
, 2018 Rapamycin, an inhibitor of mTOR complex 1 (mTORC1), improves insulin sensitivity in acute studies in vitro and in vivo by disrupting a negative feedback loop mediated by S6 kinase. We find that rapamycin has a clear biphasic effect on insulin sensitivity
Baur, Joseph A. +4 more
core +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, EarlyView.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Insulin resistance as a significant vascular risk factor has been studied in relation to cerebral small vessel disease (SVD). Evidence suggests that insulin resistance might trigger high blood pressure (BP).
Mengyuan Zhou +13 more
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RESISTANCE TO SMALL DOSES OF INSULIN IN VARIOUS CLINICAL CONDITIONS 1 [PDF]
, 1950 Norman S. Olsen, John A. Nuetzel
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Free‐Form Microfluidic Microneedle Array Patches
Advanced Functional Materials, EarlyView.Microfluidic microneedle array patches (MAPs) integrate hollow microneedles with embedded microfluidic channels, fabricated using high‐resolution 3D printing, to enable controlled transdermal delivery of liquid, mixed, or reconstituted therapeutics.
Ian A. Coates +11 more
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Journal of Tissue EngineeringGrowing evidence indicates that type 2 diabetes (T2D) is associated with an increased risk of developing Parkinson’s disease (PD) through shared disease mechanisms.
Alise Zagare +14 more
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Advanced Oral Delivery Systems for Nutraceuticals
Advanced Healthcare Materials, EarlyView.Emerging delivery technologies are explored to overcome barriers to oral nutraceutical absorption. Traditional carriers are compared with novel platforms including biodegradable polymers, MOFs, MPNs, and 3D printing. These systems enhance bioavailability, control release, and enable personalized nutrition.
Xin Yang +4 more
wiley +1 more source
Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance[S]
Journal of Lipid Research, 2011 The mechanism of FFA-induced insulin resistance is not fully understood. We have searched for effector molecules(s) in FFA-induced insulin resistance. Palmitic acid (PA) but not oleic acid (OA) induced insulin resistance in L6 myotubes through C-Jun N ...
Myoung Sook Han +13 more
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INSULIN RESISTANCE AND BODY MASS INDEX WITH REGARD TO VARIOUS THYROID STIMULATING HORMONE REFERENCE INTERVALS [PDF]
, 1969 Neval Aksoy +5 more
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