Results 121 to 130 of about 797,794 (382)

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Blood Pressure Partially Mediated the Association of Insulin Resistance and Cerebral Small Vessel Disease: A Community‐Based Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Insulin resistance as a significant vascular risk factor has been studied in relation to cerebral small vessel disease (SVD). Evidence suggests that insulin resistance might trigger high blood pressure (BP).
Mengyuan Zhou, Lerong Mei, Jing Jing, Yingying Yang, Xueli Cai, Xia Meng, Aoming Jin, Jinxi Lin, Shan Li, Hao Li, Tiemin Wei, Yongjun Wang, Yilong Wang, Yuesong Pan   +13 more
doaj   +1 more source

Excellent intra and inter-observer reproducibility of wrist circumference measurements in obese children and adolescents [PDF]

, 2016
In a previous study, we found that wrist circumference, in particular its bone component,was associated with insulin resistance in a population of overweight/obese children.
Alessia, Gallozzi, Buzzetti, Raffaella, Claudio, Chiesa, Giuseppe, Campagna, Pacifico, Lucia, Sara, Giansanti, Zampetti, Simona   +6 more
core   +1 more source

Advancing Chronic Wound Healing through Electrical Stimulation and Adipose‐Derived Stem Cells

Advanced Healthcare Materials, EarlyView.
Chronic cutaneous wounds represent significant challenges due to delayed healing and resistance to conventional treatments. This review explores the potential of combining adipose‐derived stem cells with electrical stimulation to enhance wound healing.
Qiuyue Peng, Yu Qian, Xinxin Xiao, Fengdi Gao, Guoqiang Ren, Cristian Pablo Pennisi   +5 more
wiley   +1 more source

Bayesian Analysis of Glucose Dynamics during the Oral Glucose Tolerance Test (OGTT) [PDF]

arXiv, 2020
In this paper, we propose a model of the dynamics of the blood glucose level during an Oral Glucose Tolerance Test (OGTT). This dynamic includes the action of insulin and glucagon in the glucose homeostasis process as the reaction of an oral stimulus.
arxiv  

Engineered In Vitro Multi‐Cell Type Ventricle Model Generates Long‐Term Pulsatile Flow and Modulates Cardiac Output in Response to Cardioactive Drugs

Advanced Healthcare Materials, EarlyView.
This study presents an innovative in vitro model of a human left ventricle using biofunctionalized PDMS membranes and human iPSC‐derived cardiomyocytes. The engineered ventricle demonstrates stable, long‐term pulsatile flow, and physiological responses to cardioactive drugs.
Christoph Kuckelkorn, Ebru Aksoy, Natalija Stojanovic, Laila Oulahyane, Mira Ritter, Kurt Pfannkuche, Horst Fischer   +6 more
wiley   +1 more source

Insulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinson’s disease pathology

Journal of Tissue Engineering
Growing evidence indicates that type 2 diabetes (T2D) is associated with an increased risk of developing Parkinson’s disease (PD) through shared disease mechanisms.
Alise Zagare, Janis Kurlovics, Catarina Almeida, Daniele Ferrante, Daniela Frangenberg, Armelle Vitali, Gemma Gomez-Giro, Christian Jäger, Paul Antony, Rashi Halder, Rejko Krüger, Enrico Glaab, Egils Stalidzans, Giuseppe Arena, Jens C Schwamborn   +14 more
doaj   +1 more source

A Prospective Cohort Study on IRS Gene Polymorphisms in Type 2 Diabetes Mellitus Patients during Severe/Acute Hyperglycemia Phase 1: Association with Insulin Resistance [PDF]

, 2014
Purpose: To investigate the genetic polymorphisms that may contribute to the worsening of insulin resistance in type 2 diabetes mellitus (T2DM) with severe or acute hyperglycemia.Methods: This is a prospective cohort study involving 156 T2DM patients ...
Hashim, R, Huri, HZ, Makmor-Bakry, M, Mustafa, N, Ngah, WZW   +4 more
core   +2 more sources

Self‐Doped and Biodegradable Glycosaminoglycan‐PEDOT Conductive Hydrogels Facilitate Electrical Pacing of iPSC‐Derived Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
The electrical properties and performance of conductive hydrogels based on sulfated‐glycosaminoglycan‐PEDOT (poly 3,4‐ethylenedioxythiophene) brush copolymers is studied, showing that the higher sulfation degree of heparin confers hydrogels with the highest conductivity.
Daniel Hachim, Olivia Hernández‐Cruz, James E. J. Foote, Richard Wang, Matthew W. Delahaye, Daniel J. Stuckey, Zhiping Feng, Jonathan P. Wojciechowski, Luke C. B. Salter, Junliang Lin, Sian E. Harding, Molly M. Stevens   +11 more
wiley   +1 more source

IMMUNOLOGIC STUDIES IN INSULIN RESISTANCE. III. MEASUREMENT OF AN INSULIN ANTAGONIST IN THE SERUM OF AN INSULIN-RESISTANT PATIENT BY THE BLOOD SUGAR CURVE METHOD IN MICE [PDF]

, 1947
Francis C. Lowell
openalex   +1 more source