Results 151 to 160 of about 4,252,621 (405)

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.

Journal of Clinical Investigation, 2006
Adiponectin is an adipokine that is specifically and abundantly expressed in adipose tissue and directly sensitizes the body to insulin. Hypoadiponectinemia, caused by interactions of genetic factors such as SNPs in the Adiponectin gene and environmental
T. Kadowaki, T. Yamauchi, N. Kubota, K. Hara, K. Ueki, K. Tobe   +5 more
semanticscholar   +1 more source

Engineering Assembloids to Mimic Graft‐Host Skeletal Muscle Interaction

Advanced Healthcare Materials, EarlyView.
This study develops a graft‐host skeletal muscle assembloid model combining neuromuscular organoids with tissue‐engineered constructs. Pre‐seeding decellularized muscles with myogenic cells enhances cell migration and axon invasion from the organoid. The model exhibits regenerative capacity following acute damage, advancing the understanding of human ...
Lucia Rossi, Beatrice Auletta, Luigi Sartore, Marco La Placa, Giada Cecconi, Pietro Chiolerio, Edoardo Maghin, Silvia Angiolillo, Eugenia Carraro, Onelia Gagliano, Cecilia Laterza, Nicola Elvassore, Martina Piccoli, Anna Urciuolo   +13 more
wiley   +1 more source

Correlation Analysis of Body Weight with Insulin Resistance and Leptin Levels in Farm Workers

Journal of Agromedicine and Medical Sciences (AMS)
Insulin resistance is a pathological condition resulting from impaired insulin response which causes increased insulin production as a form of compensation from pancreatic beta cells. A stable body weight can prevent insulin resistance and excessive body
Naurah Nazihah Azzalina, Sugiyanta Sugiyanta, Kristianningrum Dian Sofiana   +2 more
doaj   +1 more source

Engineered 3D Kidney Glomerular Microtissues to Model Podocyte‐Centric Diseases for the Validation of New Drug Targets

Advanced Healthcare Materials, EarlyView.
The study introduces innovative 3D microtissues that replicate the glomerular filtration barrier of the kidney, offering a novel platform for understanding podocytopathies. These microtissues simulate the glomerulus's structure and dynamics, allowing for the modeling of podocyte injuries and drug testing.
Sara Buttό, Solange Vidal, Xi Rui Zeng, Martin Rausch, Immihan Ceren Yasa, Magali P. Ferro   +5 more
wiley   +1 more source

Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjects

Journal of Lipid Research, 2012
Insulin resistance in adipose tissue increases the release of free fatty acids into the circulation, which likely contributes to impaired insulin action in liver and skeletal muscle associated with obesity.
Elisa Fabbrini, Faidon Magkos, Caterina Conte, Bettina Mittendorfer, Bruce W. Patterson, Adewole L. Okunade, Samuel Klein   +6 more
doaj  

The Role of GABA and Insulin Regulated Aminopeptidase on Insulin Resistance and GLUT4 in Prediabetes and Type 2 Diabetes Mellitus

مجله كليه طب الكندي
Background: Different proposed mechanisms for insulin resistance have been put forth to understand the relationship and changes in insulin resistance. Looking at the levels of insulin, the neurotransmitter gamma-aminobutyric acid, glucose transport type
Ismael Sadeq Khashan, Maysaa Jalal Majeed   +1 more
doaj   +1 more source

Hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy

Neurobiology of Stress, 2021
Insulin resistance is a major contributor to the neuroplasticity deficits observed in patients with metabolic disorders. However, the relative contribution of peripheral versus central insulin resistance in the development of neuroplasticity deficits ...
L.P. Reagan, H.B. Cowan, J.L. Woodruff, G.G. Piroli, J.M. Erichsen, A.N. Evans, H.E. Burzynski, N.D. Maxwell, F.Z. Loyo-Rosado, V.A. Macht, C.A. Grillo   +10 more
doaj  

Insulin resistance in haemochromatosis [PDF]

, 1966
James W. Buchanan, E. T. Young
openalex   +1 more source

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source

Insulin Resistance with High Levels of Circulating Insulin-like Activity Demonstrable in Vitro and in Vivo [PDF]

, 1961
J C Shipp, Richard O. Russell, Jürgen Steinke, M. L. Mitchell, William B. Hadley   +4 more
openalex   +1 more source