Results 161 to 170 of about 3,202,592 (310)

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Association Between Four Non-Insulin-Based Insulin Resistance Indices and the Risk of Post-Stroke Depression [PDF]

Ping Wang,* Mengchao Wang,* Zhe Xie,* Zhongwen Zhi, Yuqian Wang, Fan Liu, Yufeng Liu, Liandong Zhao Department of Neurology, the Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, Jiangsu, People’s Republic of China*These ...
Wang M, Zhi Z, Liu Y, Wang P, Zhao L, Xie Z, Wang Y, Liu F   +7 more
core  

Miro1 mediates skeletal muscle insulin resistance in type 2 diabetes. [PDF]

Nat Commun
Heintz EC, Dantas WS, Taylor AL, Zunica ERM, Belmont KP, Slone JM, Mey JT, Beyl R, Vandanmagsar B, Parry HA, Ajayi P, Glancy B, Axelrod CL, Kirwan JP.   +13 more
europepmc   +1 more source

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

Advanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai, Arathy Vasukutty, Yujin Na, Sung‐Chul Lim, Hong Seok Choi   +4 more
wiley   +1 more source

Molecular signaling networks that connect tissue dysfunction to systemic insulin resistance. [PDF]

Front Endocrinol (Lausanne)
Mir R, Algehainy NA, Jalal MM, Altayar MA, Almotairi RM, Tayeb FJ, Bedaiwi RI, Altemani FH, Almasoudi KS, Altedlawi Albalawi I, Elfaki I.   +10 more
europepmc   +1 more source

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Diabetes mellitus, insulin resistance, and metabolic syndrome in HIV-positive patients in South India

, 2011
Jyothi Idiculla1, G D Ravindra’n1, Jason D’Souza1, Girija Singh1, Sultana Furruqh21Department of Medicine, 2Department of Biochemistry, St.
G D Ravindra’n, Jason D’Souza, et al , Jyothi Idiculla   +3 more
core  

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Investigation of insulin resistance in narcoleptic patients: dependent or independent of body mass index?

, 2011
Alice Engel1,2, Jana Helfrich1, Nina Manderscheid1, Petra B Musholt3, Thomas Forst3, Andreas Pfützner3, Norbert Dahmen1,21Department of Psychiatry, University of Mainz, Germany; 2Fachklinik Katzenelnbogen, Katzenelnbogen, Germany; 3IKFE ...
Pfützner A, Forst T, Musholt PB, Engel A, Dahmen N, Manderscheid N, Helfrich J   +6 more
core  

Is Insulin Resistance the Driver or the Outcome of Diabetes Mellitus? A Critical Review. [PDF]

J Nutr Metab
Shahid S, Qamar S, Qamar F, Fatima A, Máthé E, Khaliq M.   +5 more
europepmc   +1 more source