Results 111 to 120 of about 1,475,999 (336)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

An operator expansion for integrable quantum field theories [PDF]

, 2012
A large class of quantum field theories on 1 + 1 dimensional Minkowski space, namely, certain integrable models, has recently been constructed rigorously by Lechner. However, the construction is very abstract and the concrete form of local observables in
Henning Bostelmann, D. Cadamuro
semanticscholar   +1 more source

Factorization in integrable systems with impurity

, 2005
This article is based on recent works done in collaboration with M. Mintchev, E. Ragoucy and P. Sorba. It aims at presenting the latest developments in the subject of factorization for integrable field theories with a reflecting and transmitting impurity.
A. Fring, A. Liguori, A. Liguori, A.B. Zamolodchikov, B. Davies, C.N. Yang, E. Corrigan, G. Delfino, I.V. Cherednik, L.D. Faddeev, M. Gattobigio, M. Mintchev, M. Mintchev, R.J. Baxter, S. Ghoshal, S. Murakami, S. Parke, V. Caudrelier, V. Caudrelier, V. Caudrelier, V. Caudrelier   +20 more
core   +2 more sources

Integrable Quantum Field Theories with Unstable Particles [PDF]

, 1999
A new family of S-matrix theories with resonance poles is constructed and conjectured to correspond to the Homogeneous sine-Gordon theories associated with simply laced compact Lie groups, where some of the resonance poles can be traced to the presence ...
Braden, Brazhnikov, C.R. Fernández-Pousa, Dorey, Fernández-Pousa, Fernández-Pousa, Fernández-Pousa, J.Luis Miramontes, Köberle, Miramontes, Miramontes, Takács   +11 more
core   +5 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Entanglement dynamics after a quench in Ising field theory: a branch point twist field approach

Journal of High Energy Physics, 2019
We extend the branch point twist field approach for the calculation of entanglement entropies to time-dependent problems in 1+1-dimensional massive quantum field theories.
Olalla A. Castro-Alvaredo, Máté Lencsés, István M. Szécsényi, Jacopo Viti   +3 more
doaj   +1 more source

Type II defects revisited

Journal of High Energy Physics, 2018
Energy and momentum conservation in the context of a type II, purely transmitting, defect, within a single scalar relativistic two-dimensional field theory, places a severe constraint not only on the nature of the defect but also on the potentials for ...
E. Corrigan, C. Zambon
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Entanglement content of kink excitations

Journal of High Energy Physics
Quantum one-dimensional systems in their ordered phase admit kinks as elementary excitations above their symmetry-broken vacua. While the scattering properties of the kinks resemble those of quasiparticles, they have distinct locality features that are ...
Luca Capizzi, Michele Mazzoni
doaj   +1 more source

Local charges in involution and hierarchies in integrable sigma-models

Journal of High Energy Physics, 2017
Integrable σ-models, such as the principal chiral model, ℤ T $$ {\mathbb{Z}}_T $$ -coset models for T ∈ ℤ ≥ 2 $$ T\in {\mathbb{Z}}_{\ge 2} $$ and their various integrable deformations, are examples of non-ultralocal integrable field theories described by
S. Lacroix, M. Magro, B. Vicedo
doaj   +1 more source