Results 71 to 80 of about 4,628 (266)
Hydrodynamic nonlinear response of interacting integrable systems. [PDF]
Proc Natl Acad Sci U S A, 2021 Fava M +4 more
europepmc +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A super Degasperis-Procesi equation and related integrable systems. [PDF]
Proc Math Phys Eng Sci, 2021 Gao B, Tian K, Liu QP.
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
International Journal of Mathematics and Mathematical Sciences, 2006 The Hamiltonian equation provides us an alternate description of the basic physical laws of motion, which is used to be described by Newton's law.
Xuncheng Huang, Guizhang Tu
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Algebro-Geometric Solutions for a Discrete Integrable Equation
Discrete Dynamics in Nature and Society, 2017 With the assistance of a Lie algebra whose element is a matrix, we introduce a discrete spectral problem. By means of discrete zero curvature equation, we obtain a discrete integrable hierarchy. According to decomposition of the discrete systems, the new
Mengshuang Tao, Huanhe Dong
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Formal Diagonalisation of Lax-Darboux Schemes
Моделирование и анализ информационных систем, 2015 We discuss the concept of Lax-Darboux scheme and illustrate it on well known examples associated with the Nonlinear Schro¨dinger (NLS) equation. We explore the Darboux links of the NLS hierarchy with the hierarchy of Heisenberg model, principal chiral ...
A. V. Mikhailov
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source