Results 81 to 90 of about 674,137 (288)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Тонкие химические технологии, 2017 The mathematical theory of constructing an integral transformation and the inversion formula for it for the third boundary value problem in a domain with a continuous spectrum of eigenvalues are developed.
E. M. Kartashov
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
The Control Problem for a Heat Conduction Equation with Neumann Boundary Condition
Vestnik KRAUNC: Fiziko-Matematičeskie NaukiPreviously, boundary control problems for a heat conduction equation with Dirichlet boundary condition were studied in a bounded domain. In this paper, we consider the boundary control problem for the heat conduction equation with Neumann boundary ...
Dekhkonov, F.N.
doaj +1 more source
A Neumann Boundary Term for Gravity
, 2017 The Gibbons-Hawking-York (GHY) boundary term makes the Dirichlet problem for gravity well defined, but no such general term seems to be known for Neumann boundary conditions. In this paper, we view Neumann {\em not} as fixing the normal derivative of the
Krishnan, Chethan, Raju, Avinash
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Distribution of the critical and other points in boundary problems with nonlocal boundary condition
Lietuvos Matematikos Rinkinys, 2007 In this paper the Sturm–Liouville problem with one classical and other nonlocal two-point or integral boundary condition is investigated. There are critical points of the characteristic function analysed.
Sigita Pečiulytė, Artūras Štikonas
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Boundary value problem with integral condition for a Blasius type equation
Nonlinear Analysis, 2016 The steady motion in the boundary layer along a thin flat plate, which is immersed at zero incidence in a uniform stream with constant velocity, can be described in terms of the solution of the differential equation x'''= -xx'', which satisfies the ...
Sergey Smirnov
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source