Results 71 to 80 of about 4,458,478 (284)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Problems with Missing Tricomi Condition and Analog of Frankl Condition for One Class of Mixed Type Equations

Mathematics
In this paper, for a mixed elliptic-hyperbolic type equation with various degeneration orders and singular coefficients, theorems of uniqueness and existence of the solution to the problem with a missing Tricomi condition on boundary characteristic and ...
Assel Makulbay, Mirakhmat Mirsaburov, Abdumauvlen Berdyshev, Gulbakhor Mirsaburova   +3 more
doaj   +1 more source

An Approximate Grid Solution of a Nonlocal Boundary Value Problem with Integral Boundary Condition for Laplace's Equation

ITM Web of Conferences, 2018
A new method for the solution of a nonlocal boundary value problem with integral boundary condition for Laplace's equation on a rectangular domain is proposed and justified.
Dosiyev Adıgüzel A., Reis Rifat
doaj   +1 more source

Electromagnetic Scattering Analysis of SHDB Objects Using Surface Integral Equation Method

Photonics, 2020
A surface integral equation (SIE) method is applied in order to analyze electromagnetic scattering by bounded arbitrarily shaped three-dimensional objects with the SHDB boundary condition.
Beibei Kong, Pasi Ylä-Oijala, Ari Sihvola   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Boundary value problem with integral condition for a Blasius type equation

Nonlinear Analysis, 2016
The steady motion in the boundary layer along a thin flat plate, which is immersed at zero incidence in a uniform stream with constant velocity, can be described in terms of the solution of the differential equation x'''= -xx'', which satisfies the ...
Sergey Smirnov
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Control Problem for a Heat Conduction Equation with Neumann Boundary Condition

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
Previously, boundary control problems for a heat conduction equation with Dirichlet boundary condition were studied in a bounded domain. In this paper, we consider the boundary control problem for the heat conduction equation with Neumann boundary ...
Dekhkonov, F.N.
doaj   +1 more source