Results 41 to 50 of about 9,402,651 (232)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Boundary Value Problems for Hilfer Fractional Differential Inclusions with Nonlocal Integral Boundary Conditions

Mathematics, 2020
In this paper, we study boundary value problems for differential inclusions, involving Hilfer fractional derivatives and nonlocal integral boundary conditions.
Athasit Wongcharoen, Sotiris K. Ntouyas, Jessada Tariboon   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Localized boundary-domain integral formulations for problems with variable coefficients [PDF]

, 2002
Specially constructed localized parametrixes are used in this paper instead of a fundamental solution to reduce a boundary value problem with variable coefficients to a localized boundary-domain integral or integro-differential equation (LBDIE or LBDIDE).
Mikhailov, SE
core   +4 more sources

Existence results for nonlinear boundary-value problems with integral boundary conditions

Electronic Journal of Differential Equations, 2005
In this paper, we investigate the existence of solutions for a second order nonlinear boundary-value problem with integral boundary conditions. By using suitable fixed point theorems, we study the cases when the right hand side has convex and ...
Mouffak Benchohra, Abdelkader Belarbi
doaj  

Boundary value problems for n-th order differential inclusions with four-point integral boundary conditions [PDF]

Opuscula Mathematica, 2012
In this paper, we discuss the existence of solutions for a four-point integral boundary value problem of \(n\)-th order differential inclusions involving convex and non-convex multivalued maps. The existence results are obtained by applying the nonlinear
Bashir Ahmad, Sotiris K. Ntouyas
doaj   +1 more source

Analysis of segregated boundary-domain integral equations for variable-coefficient problems with cracks [PDF]

, 2010
This is the pre-print version of the article. The official published version can be obtained from the link below - Copyright @ 2011 Wiley-BlackwellSegregated direct boundary-domain integral equation (BDIE) systems associated with mixed, Dirichlet and ...
S.E. Mikhailov, Mikhailov, SE, O. Chkadua, Natroshvili, D, Chkadua, O, D. Natroshvili   +5 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source