Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Solvability of integral boundary value problems at resonance in Rn $R^{n}$
Journal of Inequalities and Applications, 2019 Under a resonance condition involving integral boundary value problems for a second-order nonlinear differential equation in Rn $\mathbb{R}^{n}$, we show its solvability by using the coincidence degree theory of Mawhin and the theory of matrix ...
Shiying Song, Shuman Meng, Yujun Cui
doaj +1 more source
The radial integration boundary integral and integro-differential equation methods for numerical solution of problems with variable coefficients [PDF]
, 2012 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The boundary element method (BEM) has become a powerful method for the numerical solution of boundary-value problems (BVPs), due to its ability (at least ...
Al-Jawary, Majeed
core +5 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Fractional-order boundary value problems with Katugampola fractional integral conditions
Advances in Difference Equations, 2018 In this paper, we study existence (uniqueness) of solutions for nonlinear fractional differential equations with Katugampola fractional integral conditions.
Nazim I. Mahmudov, Sedef Emin
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Analysis of segregated boundary-domain integral equations for mixed variable-coefficient BVPs in exterior domains [PDF]
, 2011 This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2011 Birkhäuser Boston.Some direct segregated systems of boundary–domain integral equations (LBDIEs) associated with the mixed
Mikhailov, SE +5 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Multi-Term Fractional Differential Equations with Generalized Integral Boundary Conditions
Fractal and Fractional, 2019 We discuss the existence of solutions for a Caputo type multi-term nonlinear fractional differential equation supplemented with generalized integral boundary conditions.
Bashir Ahmad +3 more
doaj +1 more source