Results 71 to 80 of about 45,852 (266)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Existence and uniqueness of solutions for the system of integro-differential equations with three-point and nonlinear integral boundary conditions

Қарағанды университетінің хабаршысы. Математика сериясы, 2020
The paper examines a system of nonlinear integro-differential equations with three-point and nonlinear integral boundary conditions. The original problem demonstrated to be equivalent to integral equations by using Green function.
M.J. Mardanov, Y.A. Sharifov, K.E. Ismayilova   +2 more
doaj   +1 more source

Dynamical boundary conditions for integrable lattices [PDF]

Journal of Physics A: Mathematical and General, 1998
Some special solutions to the reflection equation are considered. These boundary matrices are defined on the common quantum space with the other operators in the chain. The relations with the Drinfeld twist are discussed.
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

INTEGRAL METHOD OF SOLVING HEAT-CONDUCTION PROBLEMS WITH THE SECOND-KIND BOUNDARY CONDITION. 1. BASIC STATEMENTS

Весці Нацыянальнай акадэміі навук Беларусі: Серыя фізіка-тэхнічных навук, 2018
On the basis of systems of identical equalities and integral boundary characteristics, a new algorithm of solving a boundary-value problem on the nonstationary heat conduction in a canonical body with boundary condition of the second kind has been ...
V. A. Kot
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Solvability of integral boundary value problems at resonance in Rn $R^{n}$

Journal of Inequalities and Applications, 2019
Under a resonance condition involving integral boundary value problems for a second-order nonlinear differential equation in Rn $\mathbb{R}^{n}$, we show its solvability by using the coincidence degree theory of Mawhin and the theory of matrix ...
Shiying Song, Shuman Meng, Yujun Cui
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Multi-Term Fractional Differential Equations with Generalized Integral Boundary Conditions

Fractal and Fractional, 2019
We discuss the existence of solutions for a Caputo type multi-term nonlinear fractional differential equation supplemented with generalized integral boundary conditions.
Bashir Ahmad, Madeaha Alghanmi, Ahmed Alsaedi, Sotiris K. Ntouyas   +3 more
doaj   +1 more source