Results 91 to 100 of about 783,161 (291)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Existence and uniqueness of solutions for the system of integro-differential equations with three-point and nonlinear integral boundary conditions

Қарағанды университетінің хабаршысы. Математика сериясы, 2020
The paper examines a system of nonlinear integro-differential equations with three-point and nonlinear integral boundary conditions. The original problem demonstrated to be equivalent to integral equations by using Green function.
M.J. Mardanov, Y.A. Sharifov, K.E. Ismayilova   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Fractional-order boundary value problems with Katugampola fractional integral conditions

Advances in Difference Equations, 2018
In this paper, we study existence (uniqueness) of solutions for nonlinear fractional differential equations with Katugampola fractional integral conditions.
Nazim I. Mahmudov, Sedef Emin
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Solving the Coulomb scattering problem using the complex scaling method

, 2009
Based on the work of Nuttall and Cohen [Phys. Rev. {\bf 188} (1969) 1542] and Resigno et al{} [Phys. Rev. A {\bf 55} (1997) 4253] we present a rigorous formalism for solving the scattering problem for long-range interactions without using exact ...
Abramowitz M., E. Yarevsky, Faddeev L. D., Hislop P. D., M. V. Volkov, McCurdy C. W., McCurdy C. W., N. Elander, Newton R. G., S. L. Yakovlev   +9 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Boundary Value Problems for the Helmholtz Equation for a Half-plane with a Lipschitz Inclusion [PDF]

, 2018
This paper considers to the problems of diffraction of electromagnetic waves on a half-plane, which has a finite inclusion in the form of a Lipschitz curve. The diffraction problem formulated as boundary value problem for Helmholtz equations and boundary
Lipachev, E.
core   +1 more source

Path-Integral Quantum Monte Carlo simulation with Open-Boundary Conditions

, 2017
The tunneling decay event of a metastable state in a fully connected quantum spin model can be simulated efficiently by path integral quantum Monte Carlo (QMC) [Isakov $et~al.$, Phys. Rev. Lett. ${\bf 117}$, 180402 (2016).].
Boixo, Sergio, Jiang, Zhang, Neven, Hartmut, Smelyanskiy, Vadim N.   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source