Results 51 to 60 of about 50,878 (260)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Investigation on Flooding-Resistant Performance of Integral Abutment and Jointless Bridge
Advances in Civil Engineering, 2020 Bridge washouts connected to flood events are deemed one of the main reasons for structural collapse. Compared to traditional continuous jointed bridges, integral abutment and jointless bridges (IAJBs) have better lateral stability because there are no ...
Yizhou Zhuang +5 more
doaj +1 more source
BIN1 (Bridging Integrator 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2015 Review on BIN1 (Bridging Integrator 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Thomas, S, Chang, MY, Prendergast, GC
openaire +2 more sources
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Sensors, 2019 Considering the lack of precision in transforming measured micro-electro-mechanical system (MEMS) accelerometer output signals into elevation signals, this paper proposes a bridge dynamic displacement reconstruction method based on the combination of ...
Yingquan Zou, Yunpeng Chen, Peng Liu
doaj +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
MATEC Web of Conferences, 2015 The plate girder bridge accounts for a large proportion of bridge types for its advantages of simple structure and convenience in construction. However, during the service stage, it is easy to suffer the hinge joint diseases, which badly weaken the ...
Xun Jingchuan +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source