Results 31 to 40 of about 50,878 (260)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Cyclic soil-structure interaction of integral railway bridges

Frontiers in Built Environment
Integral bridges with larger spans experience increased cyclic interaction with their backfill, particularly due to seasonal temperature changes. This can result in a continuous increase of earth pressure (during the summer positions) as well as an ...
Alexander Stastny, Alexander Stastny, Anas Emera, Vahid Galavi, Franz Tschuchnigg   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Local scour around complex pier groups and combined piles at semi-integral bridge

Journal of Hydrology and Hydromechanics, 2014
This research presents an experimental study on the scouring mechanism at semi-integral bridge piers. Based on laboratory experiments, this study focuses on the relationship between scour depth in complex pier groups and combined piles bridge and various
Akib Shatirah, Jahangirzadeh Afshin, Basser Hossein   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Dynamic Fracture Criteria Evaluation of Bridge Structural Steel

The Baltic Journal of Road and Bridge Engineering, 2011
J-integral is the main effective and commonly used tool for elastic-plastic cracked material resistance assessment. Considering ductile behavior of bridges steel integral approach is suitable for fracture toughness evaluation.
Antanas Žiliukas, Marius Gintalas
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Research on Integral Splicing Design and Construction Technology for Two Separate Spans of a Prestressed Concrete Continuous Rigid-Frame Bridge

Buildings
For an existing bridge constructed with separate spans, the ends of adjacent flanges are disconnected. The problem of separated driving may occur at the bridgehead position after traffic conversion. The idea of integral splicing two separate spans of the
Chunyao Zhong, Qiao Lu, Yangfan Li, Xuefei Shi, Jun Song, Chaoyu Zhu   +5 more
doaj   +1 more source

Integral Abutment and Jointless Bridges [PDF]

Bulletin of the Polytechnic Institute of Jassy: Constructions, Architechture Section, 2005
Integral bridges, or integral abutment and jointless bridges, as they are more commonly known in the USA, are constructed without any movement joints between spans or between spans and abutments. Typically these bridges have stub-type abutments supported
Cristian-Claudiu Comisu
doaj