Results 41 to 50 of about 50,878 (260)
Fracture toughness of old bridge steel
Budownictwo i Architektura, 2013 The subject of paper is related to problems the of fracture toughness of old steel bridge which was taken from the railway bridge, that was loaded during more than 100 years.
Eliza Mytych-Kumańska +1 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Developments and Prospects of Long-Span High-Speed Railway Bridge Technologies in China
Engineering, 2017 With the rapid developments of the high-speed railway in China, a great number of long-span bridges have been constructed in order to cross rivers and gorges. At present, the longest main span of a constructed high-speed railway bridge is only 630 m. The
Shunquan Qin, Zongyu Gao
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Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Analysis of numerical models of an integral bridge resting on an elastic half-space
Studia Geotechnica et MechanicaThe paper presents three methods of the numerical modeling of a 60 m long integral bridge structure resting on an elastic half-space. For the analysis, three bridge models were built using Abaqus FEA software.
Helowicz Andrzej
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Bridge motion of liquid in a gap between the adjacent coils of axisymmetric tubular heat exchanger
EPJ Web of Conferences, 2019 A model of a liquid bridge, which is formed between adjacent turns of an axisymmetric tubular heat exchanger, has been developed. The shape of the free surface of the bridge cross-section is determined taking into account the forces of liquid ...
Maltsev Leonid I., Podzharov Yury S.
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A Half-Bridge Voltage Balancer with New Controller for Bipolar DC Distribution Systems
Energies, 2016 This paper proposes a half-bridge voltage balancer with a new controller for bipolar DC distribution systems. The proposed control scheme consists of two cascaded Proportional Integral (PI) controls rather than one PI control for balancing the pole ...
Byung-Moon Han
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Retrofitting of a Multi-Span Simply Supported Bridge into a Semi-Integral Bridge
Applied SciencesThousands of multi-span, simply supported beam bridges with short or medium spans have been built in China. They often suffer from problems of cracks in the link slabs over piers, and the deterioration and damage of deck expansion joints at abutments. To
Zhen Xu +4 more
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