Results 71 to 80 of about 402 (214)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Blast Studies on Bridges – A State-of-the-Art Review
Electronic Journal of Structural Engineering, 2014 Blast events can lead to critical injuries along with heavy casualties in addition to disastrous structural failure, thereby giving rise to detrimental economic and social impacts, both domestically as well as internationally.
T.W.Y. Lua +5 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Maya AmericaAn K'a'ch Guzmán Marcos, an Ixil health care worker in the Ixil region, Guatemala, describes how cosmology forms an integral part of the people's identity.
An K'a'ch Guzmán Marcos
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Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
A New Space-Time Theory Unravels the Origins of Classical Mechanics for the Dirac Equation
Quantum ReportsThe Feynman path integral plays a central role in quantum mechanics, linking classical action to propagators and relating quantum electrodynamics (QED) to Feynman diagrams.
Wei Wen
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Retrofitting of a Multi-Span Simply Supported Bridge into a Semi-Integral Bridge
Applied SciencesThousands of multi-span, simply supported beam bridges with short or medium spans have been built in China. They often suffer from problems of cracks in the link slabs over piers, and the deterioration and damage of deck expansion joints at abutments. To
Zhen Xu +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source