Results 51 to 60 of about 402 (214)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Research on expansion joint for high-speed railway long-span bridges in China [PDF]

Railway Sciences
Purpose – The bridge expansion joint (BEJ) is a key device for accommodating spatial displacement at the beam end, and for providing vertical support for running trains passing over the gap between the main bridge and the approach bridge.
Hui Guo, Jinzhou Jiang, Suoting Hu, Chun Yang, Qiqi Xiang, Kou Luo, Xinxin Zhao, Bing Li, Ziquan Yan, Liubin Niu, Jianye Zhao   +10 more
doaj   +1 more source

Integrated concrete bridge

E3S Web of Conferences
Integrated concrete bridges represent a modern engineering solution that eliminates expansion joints and bearings, traditionally considered critical maintenance elements. This article provides an overview of integrated bridges, covering their structural configurations and structural interaction.
Klaudia Tutkova, Stefan Kusnir
openaire   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The use of Classical Rolling Pendulum Bearings (CRPB) for vibration control of stay-cables

MATEC Web of Conferences, 2018
Cables are efficient structural elements that are used in cable-stayed bridges, suspension bridges and other cable structures. A significant problem which arose from the praxis is the cables’ rain-wind induced vibrations as these cables are subjected to ...
Papastergiou Georgia, Raftoyiannis Ioannis   +1 more
doaj   +1 more source

An investigation on the effect of cyclic displacement on the integral bridge abutment

Journal of Civil Engineering and Management, 2014
The integral bridge abutment, as a special type of retaining wall, is subject to cyclic displacement, which is due to the daily and seasonal temperature variations. The frame of this type of bridges is rigid and jointless.
Mojtaba Movahedifar, Jafar Bolouri-Bazaz
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Behavior of integral abutment bridges considering seasonal temperature at construction completion

Soils and Foundations
Seasonal temperature-induced cyclic displacements impose repetitive stresses and cumulative deformations on the backfill behind integral abutment bridges, adversely impacting the serviceability of the integral abutment bridge (IAB).
Meihui Wang, M. Hesham El Naggar, Yewei Zheng   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source